The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

Abstract

Objective:The aim of this study was to evaluate the effect of LPRF, placed in extraction sockets, on orthodontic tooth movement (OTM).Materials and Methods:Thirty extraction sockets from eight patients (five males, three females, with a mean age of 17.37 years; range 12–25 years) requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. In one randomly selected quadrant of each jaw, the extraction socket was preserved as the experimental group by immediate placement of LPRF in the extraction socket. The other quadrant served as the control group for secondary healing. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. A piece of 0.016 × 0.022-inch stainless steel wire was used as the main arch wire. The amount of OTM was measured on the study casts at eight time points with 2-week intervals for 3 months. Analysis of random effect model was performed for the purpose of comparison between the experimental and control groups.Results:According to the random effect model, a statistically significant difference was found between the experimental and control group in rate of OTM (P = 0.006).Conclusion:According to the results, application of LPRF, as an interdisciplinary approach combining orthodontics and surgery, may accelerate OTM, particularly in extraction cases.

Platelet-Rich Fibrin in Bone Regenerative Strategies in Orthodontics: A Systematic Review

“…There was a range of different PRF protocol preparation in the included studies. Five studies [2,16,17,19,21] adjusted centrifugation to 3000 rpm for 10 min, while others used 3000 rpm for 20 min [18], 2900 rpm for 10 min [20], and 2700 rpm for 12 min [22,23].…”

“…The included studies were single centre studies. All included articles were parallel two-arm trials [2,[16][17][18][19][20][21], except the two studies that were split-mouth trials [22,23].…”

“…The reasons for the excluded records are summarised in Table A4 [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39].…”

“…Three articles investigated tooth movement and post-orthodontic stability [21][22][23]. Two studies evaluated the amount of OTM by decreasing the horizontal linear distance between the mid-marginal ridges of the adjacent teeth [22,23]. Only one study considered clinical parameters and patient feedback to evaluate pain, post-surgical inflammation, and infection [21].…”

“…The results of the quality assessment of the RCTs and CCTs studies are summarized in Figure 2. Three studies were judged as having high risk of bias, mostly due to deviations from the randomization process [2,22,23]. Two trials were judged as low risk of bias [17,19].…”