The effect of autoimmune blistering diseases on work productivity

Wang, E.Q.; Radjenovic, Melissa; Castrillón, María Adriana; Feng, Grant; Murrell, Dédée F.

doi:10.1111/jdv.15062

Cited by 10 publications

(6 citation statements)

References 25 publications

(50 reference statements)

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“…This rise may reflect increasing average life expectancy, increasing use of polypharmacy, and improved detection and diagnosis [ 5 ]. BP is associated with considerable functional impairment and distress [ 11 , 12 ] and the one-year mortality rate of BP in Europe is ~ 26.7%, although other factors should be considered (high somatic comorbidity and polypharmacy) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

et al. 2020

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Background Bullous pemphigoid (BP) is an autoimmune blistering skin disease that takes a profound physical and mental toll on those affected. The aim of the study was to investigate the bidirectional association between BP and all bullous disorders (ABD) with a broad array of psychiatric disorders, exploring the influence of prescribed medications. Methods This nationwide, register-based cohort study encompassed 6,470,450 individuals born in Denmark and alive from 1994 to 2016. The hazard ratios (HRs) of a subsequent psychiatric disorder in patients with BP/ABD and the reverse exposure and outcome were evaluated. Results Several psychiatric disorders were associated with increased risk of subsequent BP (4.18-fold for intellectual disorders, 2.32-fold for substance use disorders, 2.01-fold for schizophrenia and personality disorders, 1.92–1.85-1.49-fold increased risk for organic disorders, neurotic and mood disorders), independent of psychiatric medications. The association between BP and subsequent psychiatric disorders was not significant after adjusting for BP medications, except for organic disorders (HR 1.27, CI 1.04–1.54). Similar results emerged with ABD. Conclusion Psychiatric disorders increase the risk of a subsequent diagnosis of BP/ABD independent of medications, whereas medications used for the treatment of BP/ABD appear to account for the subsequent onset of psychiatric disorders. Clinically, an integrated approach attending to both dermatological and psychiatric symptoms is recommended, and dermatologists should remain vigilant for early symptoms of psychiatric disorders to decrease mental health comorbidity.

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Section: Introductionmentioning

confidence: 99%

Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

et al. 2020

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“…Physical symptoms include itching, skin burning and pain. Pemphigus has a strong influence on patients’ health-related quality of life (HRQoL), but it largely affects other aspects of patients’ life, such as social activities or productivity [4–6]. It has been shown that pemphigus is associated with one of the largest HRQoL impairment among chronic skin diseases [4, 5, 7–9].…”

Section: Introductionmentioning

confidence: 99%

Subjective well-being in patients with pemphigus: a path analysis

et al. 2019

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Background Pemphigus is a chronic autoimmune blistering disease of the skin and mucosa severely impairing patients' health-related quality of life (HRQoL). To date, no studies have measured subjective well-being in terms of life satisfaction in pemphigus. Our main objective was to evaluate satisfaction with life in patients with pemphigus, and to analyse its relationship with clinical severity and HRQoL. Methods A cross-sectional survey was carried out enrolling 77 patients with pemphigus. Subjective well-being was measured using the Satisfaction with Life Scale (SWLS). HRQoL was assessed by the Dermatology Life Quality Index (DLQI) and EQ-5D-5L. Disease severity was measured by Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). Results Mean ABSIS, DLQI, EQ-5D-5L and SWLS scores of patients were 11.7 (SD 17.3), 5.4 (6.8), 0.84 (0.22) and 4.76 (SD 1.52), respectively. The proportion of patients indicating extreme dissatisfaction, dissatisfaction, slightly below average in life satisfaction, average satisfaction, high satisfaction and very high satisfaction with life was 6 (7.8%), 5 (6.5%), 14 (18.2%), 16 (20.8%), 21 (27.3%) and 15 (19.5%), respectively. Life satisfaction was independent from age, gender, level of education and type of disease. A path analysis revealed that there was no direct relationship between ABSIS and SWLS (beta = − 0.09; p = 0.428); however, the following indirect path was confirmed: ABSIS → DLQI → EQ-5D-5L → SWLS. Conclusions Disease severity and HRQoL measures regularly used to assess patients' health status may be complemented with a measure of subjective well-being, such as SWLS, to achieve a more holistic assessment of patients' lives and optimise pemphigus care.

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“… 94 Due to probable stigmatization in the workplace, productivity loss is not far-fetched. 95 To quantify this phenomenon, Wang et al 96 utilized the Work Productivity and Activity Impairment Questionnaire-Specific Health Problem, a specific tool to measure productivity loss. They found that pemphigus patients with poor treatment response had significantly greater work and activity impairment than those with a proper response.…”

Section: Daily Activitiesmentioning

confidence: 99%

Burden of pemphigus vulgaris with a particular focus on women: A review

Kianfar

Dasdar

Mahmoudi

et al. 2022

International Journal of Women’s Dermatology

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Pemphigus vulgaris is a chronic autoimmune mucocutaneous blistering disorder. Apart from the disease itself, other aspects of patients’ life, including psychological, social, and financial, can be affected. Women are particularly more disposed to the impact of the disease due to their physiological characteristics, the specific periods of pregnancy and lactation as well as their social and familial role. In this review, we summarized the burden of pemphigus vulgaris on various aspects of women’s lives. It is essential to understand these problems and provide appropriate support for patients with such a burdensome disease.

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The effect of autoimmune blistering diseases on work productivity

Abstract: Autoimmune blistering diseases negatively impacts upon work productivity and activity. Stigmatization was common in the workplace which leads to increased stress, itself a stimulator of pemphigus.

Cited by 10 publications

References 25 publications

Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

Subjective well-being in patients with pemphigus: a path analysis

Burden of pemphigus vulgaris with a particular focus on women: A review

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