The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ

Bian, Qian; Kato, Takahiro A.; Monji, Akira; Hashioka, Sadayuki; Mizoguchi, Yoshikazu; Horikawa, Hideki; Kanba, Shigenobu

doi:10.1016/j.pnpbp.2007.06.031

Cited by 148 publications

(95 citation statements)

References 61 publications

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“…Risperidone, another atypical antipsychotic, inhibited the productions of NO, IL-1β, IL-6 and TNF-α from the IFN-γ activated microglia 109 . Similar anti-inflammatory effects were also shown by perospirone and quetiapine, another two atypical antipsychotics 110 . In a recent study, both haloperidol and risperidone inhibited the secretion of S100B following IL-6 stimulation in C6 glioma cells 111 .…”

Section: Anti-inflammatory Effects Of Antipsychoticssupporting

confidence: 59%

Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence

Xu¹

2015

Pharmacologia

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Background: Schizophrenia is a heterogeneous mental disorder with a variety of symptoms. Although, there are no pathognomonic abnormalities in brains of schizophrenia patients, recent years have witnessed research progresses in revealing pathologic changes in cellular and molecular levels. Objective: This article reviewed recent human studies showing neuroimmune alterations in schizophrenia patients and offered explanations for roles of neuroinflammation in the pathogenesis of schizophrenia by citing some of experimental data from non-human studies. The focus of this review was put on pharmacological and therapeutic evidence pointing to a recommendation of anti-inflammatory treatment for patients with schizophrenia. Particularly, it provided compelling evidence supporting an anti-inflammatory effect of antipsychotics by reviewing a relatively large body of studies in the categories of in vitro, animals and humans. Conclusion: Then, it reviewed recent clinical trials with minocycline, a second-generation tetracycline, or the selective COX-2 inhibitor celecoxib. Most of these clinical trials provided promising results of superior beneficial treatment effects as the consequence of co-administration of standard antipsychotic drugs and anti-inflammatory compounds, compared with antipsychotic drugs alone.

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Section: Anti-inflammatory Effects Of Antipsychoticssupporting

confidence: 59%

Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence

Xu¹

2015

Pharmacologia

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“…The role of inflammation in depression has received the greatest attention; however, inflammatory pathways are implicated in the etiology of other disorders, such as schizophrenia. As with the atypical antipsychotics, which have new data showing a diversity of mechanisms of action, including on inflammation, 85 brain-derived neurotrophic factor 86 and oxidative stress, 87 efficacy may turn out to be a summative interaction of effects on various pathways.…”

Section: Discussionmentioning

confidence: 99%

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Dean

Giorlando

Berk

2011

J Psychiatry Neurosci

415

314

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There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.

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“…Data from the CATIE study on schizophrenia suggest that olanzapine is associated with a reduction in inflammatory markers [46]. In vitro studies showed that quetiapine reduces the TNF-α response to IFN-γ stimulation [35]. Antidepressants may normalize serum levels of inflammatory cytokines, including IL-1β, IL-6, TNF-α and IFN-γ, in major depression [47].…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence for a strong effect of clozapine on the production of IL-10 and an inhibition of the production of proinflammatory cytokines such as TNF-α and IL-6 [17,31,33,34]. Quetiapine inhibits TNF-α release from IFN-γ-activated microglia [35]. …”

Section: Introductionmentioning

confidence: 99%

Selected Cytokine Profiles during Remission in Bipolar Patients

Remlinger-Molenda

Wójciak

Michalak³

et al. 2012

Neuropsychobiology

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Objectives: The aim of the study was to examine the cytokine status in bipolar patients during immediate remission after acute episodes of mania or depression and in patients with sustained (≥6 months) remission, compared with healthy controls. Methods: The study was performed on 121 bipolar patients, of whom 35 were in immediate remission after mania, 41 were in immediate remission after depression, and 45 were in >6-month remission on lithium monotherapy or lithium combined with other drugs. The control group consisted of 78 healthy individuals without any history of psychiatric or immunological illnesses. Serum concentrations of IL-1β, IL-2, IL-6, IL-10, TNF-α and IFN-γ were determined using the Human Th1/Th2 Cytometric Bead Array method. Results: The concentration of IL-10 was higher in patients in remission after mania and the concentration of IFN-γ was higher in those in remission after depression than in healthy controls. On the other hand, cytokine concentrations in patients with sustained remission were not different from those of healthy subjects. Conclusions: The results obtained in this study show that sustained remission in bipolar patients achieved mostly by lithium maintenance brings the cytokine status to a level similar to healthy control subjects.

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The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ

Cited by 148 publications

References 61 publications

Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence

Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

Selected Cytokine Profiles during Remission in Bipolar Patients

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