The effect of atropine and albuterol aerosols on the human bronchial response to histamine

Casterline, Charlotte L.; Evans, Richard; Ward, George W.

doi:10.1016/0091-6749(76)90207-4

Cited by 72 publications

(17 citation statements)

References 11 publications

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“…The anticholinergic effect could be exerted either by blocking a vagal reflex initiated by histamine stimulating irritant receptors directly and/or indirectly via bronchoconstriction, or by blocking increased acetylcholine release at the cholinergic receptor on smooth muscle cells as a result of presynaptic effects of histamine (Shore et al 1983). Cholinergic pathways for histamine effect have previously been thought to be small in man (Casterline et al 1976), or to be explained by an anticholinergic agent's bronchodilator effect rather than directly blocking a cholinergic component of histamine effect (Bandouvakis et al 1981). The present study favours the former conclusion since there was no relationship between bronchodilator effect and protection against histamine-induced bronchoconstriction.…”

Section: Discussionsupporting

confidence: 61%

Combined Bronchodilator Protection Against Histamine‐induced Bronchoconstriction in Man

Ruffin

Meki²,

Alpers

1987

Clin Exp Pharma Physio

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Sixteen stable asthmatics had the protective effects of inhaled fenoterol (200 micrograms) and inhaled ipratropium bromide (60 micrograms) against standardized histamine inhalation tests at 1 h examined in a randomized double blind fashion. There was no significant difference in the baseline forced expired volume in 1 s (FEV1) for the two study days (P greater than 0.05). There was an increase in FEV1 at 1 h on the fenoterol and ipratropium day compared with the fenoterol day (0.26 versus 0.17 l; P less than 0.05). The geometric mean provocative concentration of histamine to cause a 20% fall in FEV1 (PC20) was 6.31 mg/ml after fenoterol and 8.51 mg/ml after fenoterol and ipratropium (P = 0.038). There was no significant relationship between bronchodilator effect of the bronchodilators and the increase in PC20 from pre-study values, r = 0.307 (P = 0.25) for fenoterol alone and r = 0.195 (P = 0.47) for fenoterol and ipratropium. The relationship between pre-study histamine responsiveness and the increase in PC20 caused by the bronchodilators just failed to reach statistical significance, r = -0.441 (P = 0.09) for fenoterol alone and r = -0.47 (P = 0.06) for fenoterol and ipratropium. The study has shown a greater right shift of histamine responsiveness for combined inhaled fenoterol and ipratropium compared with inhaled fenoterol alone in this group of asthmatics.

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Section: Discussionsupporting

confidence: 61%

Combined Bronchodilator Protection Against Histamine‐induced Bronchoconstriction in Man

Ruffin

Meki²,

Alpers

1987

Clin Exp Pharma Physio

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“…The only significant difference between the two groups of asthmatic patients was the baseline FEV|. The greater baseline obstruction of patients with intrinsic asthma may have influenced the bronchial response to inhaled methacholine [4] but not the response to the diving maneuver [32], Although we have so far merely demonstrated an association of choliner gic hyperreactivity with bronchial asthma, and not a mechanism of airway disease, the data of our study should, nevertheless, be of some significance in the debate about the role of the parasympathetic system in the bronchomotor response to antigens [9,10], to pharmacological agonists [33][34][35][36][37] and to physical stimuli [7].…”

Section: Discussionmentioning

confidence: 69%

Parasympathetic Activity Assessed by Diving Reflex and by Airway Response to Methacholine in Bronchial Asthma and Rhinitis

Sturani¹,

Sturani

Tosi³

1985

Respiration

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It has been suggested that airway hyperreactivity in asthma is associated with increased parasympathetic tone. We have accordingly assessed parasympathetic responsiveness in five groups of subjects (17 normal controls, 8 patients with extrinsic rhinitis, 6 with intrinsic rhinitis, 10 extrinsic asthmatic patients, 7 intrinsic asthmatic patients) by examining their responses to both diving reflex and methacholine inhalation challenge. The mean fall in heart rate during the diving test was significantly greater in asthmatic subjects than in normal controls and in patients with rhinitis. The diving-induced bradycardia was significantly greater in intrinsic than in extrinsic asthmatic subjects. There was a good correlation between the drop in heart rate during diving test and the provocation dose of methacholine producing a 45 % decrease in specific airway conductance both in patients with rhinitis and in asthmatic patients. There was a less good correlation between diving response and clinical severity score in the same asthmatic patients. These results indicate that intrinsic asthma is associated with a marked degree of cholinergic hyperreactivity. The diving test seems to provide an accurate method for the analysis of the parasympathetic system in asthma.

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“…Analo gously to the findings in animals, it was also found that ipratropium bromide has a favorable effect against bronchospasm elicit ed in humans by acetylcholine inhalations [26,33], However, it had little or no effect with histamine or serotonin inhalation. Also, prior administration of ipratropium bromide was not completely effective in reducing the increase of airway resistance evoked by allergen challenge [4,7,14,18,19,26,27,34,35].…”

Section: Discussionmentioning

confidence: 99%

Immunological Release of Histamine from Human Lung

Morr¹

1979

Respiration

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The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acetylcholine at a concentration of 1 × 10^-7M increased the antigen-induced release of histamine by approximately 41%. When the lung tissue was treated with ipratropium bromide before acetylcholine, the competitive inhibition of the cholinergic receptor almost completely abolished this acetylcholine-induced increase of histamine release. Therefore, in our opinion, anticholinergic agents are primarily useful in vagus-controlled chronic obstructive ventilatory disorders; they are of secondary importance in allergic bronchial asthma.

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The effect of atropine and albuterol aerosols on the human bronchial response to histamine

Cited by 72 publications

References 11 publications

Combined Bronchodilator Protection Against Histamine‐induced Bronchoconstriction in Man

Combined Bronchodilator Protection Against Histamine‐induced Bronchoconstriction in Man

Parasympathetic Activity Assessed by Diving Reflex and by Airway Response to Methacholine in Bronchial Asthma and Rhinitis

Immunological Release of Histamine from Human Lung

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