The Effect of Atrial Fibrillation on Inpatient Outcomes of Patients with Acute Pancreatitis: A Two-year National Inpatient Sample Database Study

Jamal, Shakeel; Khan, Muhammad Zatmar; Kichloo, Asim; Edigin, Ehizogie; Bailey, Beth A.; Aljadah, Michael; Hussaian, Ishtiaq; Rahman, Asad Ur; Ahmad, Muhammad Imtiaz; Kanjwal, Khalil

doi:10.19102/icrm.2020.111205

Cited by 6 publications

(8 citation statements)

References 30 publications

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“…Our study however has some limitations. (i) NIS uses claims data based on ICD-10 codes rather than clinical data 29. (ii) ICD-10 codes do not grade severity; therefore, we cannot discern if SLE disease severity may have had affected outcomes of AF hospitalizations.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of Atrial Fibrillation Hospitalizations in Patients with Systemic Lupus Erythematosus: A Report from the National Inpatient Sample

Pavon

Shahi

Akuna

et al. 2021

Journal of Investigative Medicine

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This study compares outcomes of patients admitted for atrial fibrillation (AF) with and without coexisting systemic lupus erythematosus (SLE). The primary outcome was inpatient mortality. Hospital length of stay (LOS), total hospital charges, odds of undergoing ablation, pharmacologic cardioversion and electrical cardioversion were secondary outcomes of interest. Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 database. The NIS was searched for adult hospitalizations with AF as principal diagnosis with and without SLE as secondary diagnosis using International Classification of Diseases, Tenth Revision, Clinical Modification codes. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. There were over 71 million discharges included in the combined 2016 and 2017 NIS database. 821,630 hospitalizations were for adult patients, who had a principal diagnosis of AF, out of which, 2645 (0.3%) had SLE as secondary diagnosis. Hospitalizations for AF with SLE had similar inpatient mortality (1.5% vs 0.91%, adjusted OR (AOR): 1.0, 95% CI 0.47 to 2.14, p=0.991), LOS (4.2 vs 3.4 days, p=0.525), total hospital charges ($51,351 vs $39,121, p=0.056), odds of undergoing pharmacologic cardioversion (0.38% vs 0.38%, AOR: 0.90, 95% CI 0.22 to 3.69, p=0.880) and electrical cardioversion (12.9% vs 17.5%, AOR 0.87, 95% CI 0.66 to 1.15, p=0.324) compared with those without SLE. However, SLE group had increased odds of undergoing ablation (6.8% vs 4.2%, AOR: 1.9, 95% CI 1.3 to 2.7, p<0.0001). Patients admitted for AF with SLE had similar inpatient mortality, LOS, total hospital charges, likelihood of undergoing pharmacologic and electrical cardioversion compared with those without SLE. However, SLE group had greater odds of undergoing ablation.

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Section: Discussionmentioning

confidence: 99%

“…(i) NIS uses claims data based on ICD-10 codes rather than clinical data. 29 (ii) ICD-10 codes do not grade severity; therefore, we cannot discern if SLE disease severity may have had affected outcomes of AF hospitalizations. (iii) NIS database contains reports on hospitalizations, rather than individual patients.…”

Section: Original Researchmentioning

confidence: 99%

Outcomes of Atrial Fibrillation Hospitalizations in Patients with Systemic Lupus Erythematosus: A Report from the National Inpatient Sample

Pavon

Shahi

Akuna

et al. 2021

Journal of Investigative Medicine

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“…Due to the nature of the NIS database, we can delineate important sociodemographic characteristics of a relatively rare disease such as SSc. Our study, however, has some limitations: (1) we included hospitalizations and clinical events based on ICD-10 codes which were created for billing purposes26; (2) ICD-10 codes do not grade severity, therefore, we cannot discern if SSc disease severity may have had affected outcomes of hospitalizations; (3) NIS database contains reports on hospitalizations, rather than individual patients27; (4) data on immunosuppressant use and medication compliance are not available in NIS28 29; (5) causation cannot be obtained from NIS studies, only association can be obtained; (6) duration of illness such as lung involvement cannot be obtained from NIS studies 30…”

Section: Discussionmentioning

confidence: 99%

Lung Involvement in Systemic Sclerosis is Associated with Adverse Hospital Outcomes: Insights from the National Inpatient Sample

Odion

Guraya

Muojieje

et al. 2021

Journal of Investigative Medicine

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This study aimed to compare outcomes of systemic sclerosis (SSc) hospitalizations with and without lung involvement. The primary outcome was inpatient mortality while secondary outcomes were hospital length of stay (LOS) and total hospital charge. Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 database. This database is the largest collection of inpatient hospitalization data in the USA. The NIS was searched for SSc hospitalizations with and without lung involvement as principal or secondary diagnosis using International Classification of Diseases 10th Revision (ICD-10) codes. SSc hospitalizations for patients aged ≥18 years from the above groups were identified. Multivariate logistic and linear regression analysis was used to adjust for possible confounders for the primary and secondary outcomes, respectively. There were over 71 million discharges included in the combined 2016 and 2017 NIS database. 62,930 hospitalizations were for adult patients who had either a principal or secondary ICD-10 code for SSc. 5095 (8.10%) of these hospitalizations had lung involvement. Lung involvement group had greater inpatient mortality (9.04% vs 4.36%, adjusted OR 2.09, 95% CI 1.61 to 2.73, p<0.0001), increase in mean adjusted LOS of 1.81 days (95% CI 0.98 to 2.64, p<0.0001), and increase in mean adjusted total hospital charge of $31,807 (95% CI 14,779 to 48,834, p<0.0001), compared with those without lung involvement. Hospitalizations for SSc with lung involvement have increased inpatient mortality, LOS and total hospital charge compared with those without lung involvement. Collaboration between the pulmonologist and the rheumatologist is important in optimizing outcomes of SSc hospitalizations with lung involvement.

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“…There are two peaks of death occurred in SAP: the first, within two weeks of acute onset, due to multiple organs failure which results from the systemic inflammatory storm, and the second, two weeks after the acute bout, triggered by multi-organ damage with sepsis caused by infected pancreatic necrosis (IPN). [3][4][5] Neutrophils, the most abundant white blood cells in the human body, play a pivotal role in the host defense. Neutrophils can kill invading pathogens via phagocytosis, degranulation, and reactive oxygen species (ROS) production.…”

Section: Introductionmentioning

confidence: 99%

Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis

Kang

Yang²,

Zhu³

et al. 2023

Chinese Medical Journal

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Severe acute pancreatitis (SAP) is a life-threatening acute abdominal disease with two peaks of death: the first in the early stage, characterized by systemic inflammatory response-associated organ failure; and the second in the late stage, characterized by infectious complications. Neutrophils are the main immune cells participating in the whole process of SAP. In addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens, neutrophil extracellular traps (NETs) also play an important roles in inflammatory reactions. We reviewed the role of NETs in the occurrence and development of SAP and its fatal complications, including multiple organs injury, infected pancreatic necrosis, and thrombosis. This review provides novel insights into the involvement of NETs throughout the entire process of SAP, showing that targeting NETs might be a promising strategy in SAP treatment. However, precision therapeutic options targeting NETs in different situations require further investigation.

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The Effect of Atrial Fibrillation on Inpatient Outcomes of Patients with Acute Pancreatitis: A Two-year National Inpatient Sample Database Study

Cited by 6 publications

References 30 publications

Outcomes of Atrial Fibrillation Hospitalizations in Patients with Systemic Lupus Erythematosus: A Report from the National Inpatient Sample

Outcomes of Atrial Fibrillation Hospitalizations in Patients with Systemic Lupus Erythematosus: A Report from the National Inpatient Sample

Lung Involvement in Systemic Sclerosis is Associated with Adverse Hospital Outcomes: Insights from the National Inpatient Sample

Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis

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