Sexuality, which plays an essential and significant role in human life, is provided through healthy sexual organs. Therefore, any disease in the genital area, including vaginitis, can interfere with these tendencies and thus affect the quality of life of the individual. The researchers, therefore, conducted a study aimed at comparing sexual satisfaction in pregnant women with vaginal candidiasis. This is a cross-sectional study to evaluate the effect of Candida vaginitis infection on sexual satisfaction that should be considered in healthy individuals and comparative work. Therefore, in this study, 160 pregnant mothers referred to the gynecology clinic, Shahid Beheshti Hospital, Tehran were selected by convenience sampling method and divided into two groups of healthy pregnant women and vaginal candidiasis women (each group 80 people). Data were collected using the Larson Sexual Satisfaction Questionnaire. After data collection, data were analyzed in SPSS software and analyzed by independent t-test. The results showed that sexual satisfaction in healthy pregnant women was slightly higher than pregnant women with vaginal candidiasis, and there was a significant difference between the two groups regarding sexual satisfaction (p <0.05). These results suggest that there is a relationship between sexual satisfaction and Candida infection. Regarding the difference of sexual satisfaction in the group of pregnant women with vaginal candidiasis and healthy pregnant women, it can be concluded that the rate of sexual satisfaction with the vaginal candidate will be effected and makes problems and disorders.