The Effect of Aspirin on Adherence of Slime–Producing, Coagulase-Negative Staphylococci to Vascular Grafts

Demirağ, Mustafa Kemal; Esen, Şaban; Zivalioglu, Muammer; Leblebicioğlu, Hakan; Keçeligil, Hasan Tahsin

doi:10.1016/j.avsg.2006.06.006

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…However, the mechanism of NASIDs impact on bacterial biofilm formation has not been fully explained. It is considered that this kind of effect should be due to inhibition of bacterial initial attachment (Demirag, Esen, Zivalioglu, Leblebicioglu, & Keceligil, ; Muller, Al‐Attar, Wolff, & Farber, ), reduction of EPS and protein syntheses (Farber & Wolff, ; Muller et al., ), and change of hydrophobicity (Naves et al., ). Another possible interpretation for biofilm inhibition is their impact on the QS system (Ulusoy & Bosgelmez‐Tinaz, ).…”

Section: Discussionmentioning

confidence: 99%

Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa

et al. 2017

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Microbial biofilms are communities of surface‐adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000‐fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa biofilm has necessitated the development of antimicrobial agents. Here, we have investigated the antibiofilm effect of meloxicam against P. aeruginosa PAO1 and its potential mechanisms. Further, we have explored whether meloxicam could enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobials. Here, we found that meloxicam could significantly inhibit PAO1 biofilm formation in a dose‐dependent manner at the concentration without influence on planktonic cell growth. Meloxicam could also significantly inhibit the motilities, production of extracellular matrix, and expression of quorum sensing‐related genes and virulence factors of PAO1. Furthermore, synergistic interaction was observed when meloxicam combined with tetracycline, gentamicin, tobramycin, ciprofloxacin, ceftriaxone, ofloxacin, norfloxacin, ceftazidime, and DNase at subminimal inhibitory concentrations against PAO1 bioiflm. Collectively, our study lays the foundation for further investigation of repurposing meloxicam as a topical antibiofilm agent to treat P. aeruginosa biofilm‐related infections.

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Section: Discussionmentioning

confidence: 99%

Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa

et al. 2017

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“…Clinically, aspirin treatment was associated with a significant decrease in risk of Staphylococcus aureus bacteraemia (Sedlacek et al 2007). Aspirin was recommended to be given postoperatively to decrease graft infections emerging due to coagulase-negative staphylococcus owing to its antiadhesion properties (Demirag et al 2007). Interestingly, it was shown to decrease the prevalence of nasal carriage rate of Staphylococcus aureus (Karabay et al 2006).…”

Section: Discussionmentioning

confidence: 99%

The assessment of the antibacterial and antifungal activities of aspirin, EDTA and aspirin-EDTA combination and their effectiveness as antibiofilm agents

Al‐Bakri

Othman

Bustanji

2009

Journal of Applied Microbiology

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Aims: To evaluate the antimicrobial activities of aspirin, EDTA and an aspirin‐EDTA (A‐EDTA) combination against Pseudomonas aeruginosa, Escherichia coli and Candida albicans in planktonic and biofilm cultures. Methods and Results: Minimal inhibitory concentrations (MIC) and minimal biocidal concentrations (MBC) were determined using twofold broth microdilution and viable counting methods, respectively. Aspirin’s recorded MIC values ranged from 1·2 to 2·7 mg ml−1. Checkerboard assay demonstrated a synergism in antimicrobial activity upon combination. Aspirin’s minimal biofilm eradication concentration values (MBEC) against the established biofilms ranged between 1·35 and 3·83 mg ml−1. A complete eradication of bacterial biofilms was achieved after a 4‐h treatment with the A‐EDTA combination. Conclusion: Both aspirin and EDTA possess broad‐spectrum antimicrobial activity for both planktonic and biofilm cultures. Aspirin used at the MBEC for 24 h was successful in eradicating P. aeruginosa, E. coli and C. albicans biofilms established on abiotic surfaces. Moreover, the exposure to the A‐EDTA combination (4 h) effected complete bacterial biofilm eradication. Significance and Impact of the Study: There is a continuous need for the discovery of new antimicrobial agents. Aspirin and EDTA are ‘nonantibiotic drugs’, the combination of which can be used successfully to treat and eradicate biofilms established on abiotic surfaces.

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“…In vitro studies have shown that salicylic acid, the major metabolite of aspirin, decreases the adherence of staphylococcus to synthetic graft material (92) as well as endothelial cells (93). Additionally, production of the cytokine, interleukin‐6, by endothelial cells appears to be decreased in vitro using salicylic acid (93).…”

Section: Prophylaxismentioning

confidence: 99%

Infection Associated with Tunneled Hemodialysis Catheters

Beathard¹,

Urbanes²

2008

Seminars in Dialysis

107

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The use of tunneled dialysis catheters to deliver hemodialysis treatment may be associated with major problems. For this reason their use should be minimized as much as possible. Infection is the most serious of these problems. This complication causes very significant morbidity and mortality and has emerged as the primary barrier to long-term catheter use. Bacteremia is the most serious type of infection associated with catheter use. It can result in metastatic infection and even lead to death of the patient. Prophylaxis is important to decrease the risk of infection. The use of an antibiotic ointment at the exit site until it has healed and the long-term use of a dressing to cover the exit site are effective in decreasing the incidence of exit-site infection. With optimal catheter-use management, it should be possible to reduce the incidence of catheter-related bacteremia (CRB) to a level in the range of 1 ⁄ 1000 catheter days. Antibiotic and antimicrobial locking solutions show promise and may, if verified in appropriate clinical studies, prove to be important adjuncts to the management of catheterdependent patients. Aspirin has been shown to have anti-staphylococcal activity and warrants further clinical evaluation. The diagnosis of CRB is based upon positive blood cultures in association with typical clinical features. If a simple routine blood culture is positive, along with a high clinical probability based upon the patient's signs and symptoms, the sensitivity and specificity of the diagnosis is greater than 75%. CRB is in reality a biofilm infection and must be treated as such. Treatment needs to focus on appropriate systemic antibiotics which should be continued for a minimum of 3 weeks and catheter management to remove the biofilm. Catheter exchange has been shown to be effective and should be performed based upon the clinical presentation of the patient. While treatment with a combination of systemic antibiotics and antibiotic locking solution may be effective for gramnegative infections, this approach does not appear to be a good choice for Staphylococcus aureus CRB.The use of a tunneled dialysis catheter (TDC) to deliver hemodialysis (HD) treatment may be associated with major problems. Catheter dysfunction (inadequate flow) secondary to thrombosis and catheter-related infections are common occurrences. Although catheter dysfunction is the more common of the two complications, infection related to the use of a catheter is the more serious problem, representing a very significant cause of morbidity and mortality and has emerged as the primary barrier to long-term catheter use. The overall incidence of this problem can be appreciated from a review of the data generated by the HEMO study. This was a study of 1846 randomized HD patients designed primarily to evaluate the efficiency of dialysis, but secondarily also evaluated infection-related deaths and first infectionrelated hospitalizations. Catheters were present in 32% of all study patients admitted with access-related infection, even thoug...

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The Effect of Aspirin on Adherence of Slime–Producing, Coagulase-Negative Staphylococci to Vascular Grafts

Cited by 14 publications

References 25 publications

Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa

Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa

The assessment of the antibacterial and antifungal activities of aspirin, EDTA and aspirin-EDTA combination and their effectiveness as antibiofilm agents

Infection Associated with Tunneled Hemodialysis Catheters

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