The Effect of Asparagus Extract on Pancreatic Cancer: An Intriguing Surprise

Xiao, Huaping; Deng, Zuliang; Hough, Jacob; Chen, Xuhui; Zhu, Ziwen; Jacob, Louis; Dominguez, Aldo; Shi, Tianru; Schmidt, Joseph D.; Bai, Qian; Wakefield, Mark R.; Fang, Yujiang

doi:10.21873/anticanres.15721

Cited by 5 publications

(4 citation statements)

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“…Due to its multitargeted nature, TCM is a very efective approach to treating a wide range of diseases [4,19]. It has been reported that polysaccharide, saponin, and favonoid extracts from ASP, a tuberous vegetable of the lily family, are anticancer agents in lung and bladder cancers [6,20]. As a result of ASP extracts exerting prooxidant activity on breast tumor cells, they have a combined lethal efect with menaquinone [21].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Asparagus against Glioblastoma

Luo

Xing

et al. 2023

Journal of Food Biochemistry

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Glioblastoma (GBM) is the most malignant primary brain tumor, and there is an urgent need to explore effective therapeutic strategies to improve the prognosis of GBM patients. Asparagus (ASP) is a widely grown plant with a rich pharmacological profile that has been used to treat various cancers. However, its role in GBM remains unclear. In the study, we confirmed the inhibitory effect of ASP on GBM and explored the target and mechanism of ASP through network pharmacology, molecular docking, and molecular biology experiments. We found that P53 is a potent target of ASP for GBM treatment, and its pharmacological mechanism is the activation of p53-dependent apoptosis. Our research provides an objective basis for the development and clinical application of ASP in GBM patients.

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Section: Discussionmentioning

confidence: 99%

Network Pharmacology Analysis and Experimental Pharmacology Study Explore the Mechanism of Asparagus against Glioblastoma

Luo

Xing

et al. 2023

Journal of Food Biochemistry

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“…Asparagus is considered a nutritious food due to its low-caloric content, high fiber content, and presence of various phytochemicals such as fructose, flavonoids, vitamins, saponins, or cinnamic acid [ 1 ]. These constituents are reported to have various biological activities like stress relief [ 2 ], anti-cancer [ 3 ], and so on.…”

Section: Introductionmentioning

confidence: 99%

Physiological and transcriptome analysis of changes in endogenous hormone and sugar content during the formation of tender asparagus stems

He,

Chen,

et al. 2024

BMC Plant Biol

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Asparagus is a nutritionally dense stem vegetable whose growth and development are correlated with its quality and yield. To investigate the dynamic changes and underlying mechanisms during the elongation and growth process of asparagus stems, we documented the growth pattern of asparagus and selected stem segments from four consecutive elongation stages using physiological and transcriptome analyses. Notably, the growth rate of asparagus accelerated at a length of 25 cm. A significant decrease in the concentration of sucrose, fructose, glucose, and additional sugars was observed in the elongation region of tender stems. Conversely, the levels of auxin and gibberellins(GAs) were elevated along with increased activity of enzymes involved in sucrose degradation. A significant positive correlation existed between auxin, GAs, and enzymes involved in sucrose degradation. The ABA content gradually increased with stem elongation. The tissue section showed that cell elongation is an inherent manifestation of stem elongation. The differential genes screened by transcriptome analysis were enriched in pathways such as starch and sucrose metabolism, phytohormone synthesis metabolism, and signal transduction. The expression levels of genes such as ARF, GA20ox, NCED, PIF4, and otherswere upregulated during stem elongation, while DAO, GA2ox, and other genes were downregulated. The gene expression level was consistent with changes in hormone content and influenced the cell length elongation. Additionally, the expression results of RT-qPCR were consistent with RNA-seq. The observed variations in gene expression levels, endogenous hormones and sugar changes during the elongation and growth of asparagus tender stems offer valuable insights for future investigations into the molecular mechanisms of asparagus stem growth and development and provide a theoretical foundation for cultivation and production practices.

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“…In recent studies, some extracts of Asparagus genus with potential action against various tumor and cancer cells, were detected (Xiao et al, 2022;Xu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%