The Effect of Asian Influenza on the Outcome of Pregnancy, Baltimore, 1957-1958

Further Studies on Episodic Occurrence of Congenital Dysgenetic Hypothyroidism in Osaka, Japan

“…Although the correlation may be spurious this is suggestive data. Contradictory results have been reported concerning the relationship between maternal influenza and fetal anomalies [17][18][19][20]. A preliminary survey by Miyai et al [21,22] failed to obtain significant positive data of various antiviral antibodies including influenza in CH.…”

Risks associated with viral infections during pregnancy

“…They are more susceptible to rubeola (also known as measles), and the infection is more likely to cause death (98,99). Furthermore, during the 2009 H1N1 influenza pandemic, pregnant women developed more severe flu-related complications, in some cases leadings to hospitalization and death, when compared with the general population (41,62,64,(100)(101)(102)(103)(104)(105), and this was confirmed to have also occurred during the 1918 H1N1 (106,107) and 1957 H5N1 pandemics (108,109). Despite these clear associations between pregnancy and virus-induced morbidity, there is still little known about how pregnancy affects the mother's response to viral pathogens.…”

Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy

“…[5][6][7] In addition, adverse effects of influenza on perinatal and early neonatal outcomes have also been observed. [8][9][10] The epidemiological profile of the A/H1N1v influenza virus that emerged in 2009 was different from normal seasonal influenza, in that working-age adults and children suffered higher rates of complications (including hospitalisations) than the elderly. The effect was noted to be most pronounced in individuals with underlying comorbidities and during pregnancy, in whom clear signals regarding the relationship between the premorbid state and influenza illness severity were observed, despite being based on small data sets.…”

“…Evidence suggests that this effect can be seen with seasonal influenza, 1,2,24-26 but is far more evident with pandemic influenza, the most notable observations arising from the 1957 A/H2N2 pandemic, during the second and third trimesters of pregnancy. [3][4][5][6][7][8][9][10][11][12] In addition, adverse effects of influenza on perinatal and early neonatal outcomes have also been observed. 2,13,14 The epidemiological profile of the emergent H1N1v swine influenza virus suggests that it is behaving differently from normal seasonal influenza, in that working age adults and children appear to be suffering higher Title Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v (swine influenza) during pregnancy…”