The Effect of Ascorbic Acid and l-Histidine Therapy on Acute Mammary Inflammation in Dairy Cattle

Abstract

Ascorbic acid and L-histidine were investigated as antioxidant therapies for acute mammary inflammation. Mastitis was induced in eight nonpregnant Holstein cows by intramammary infusion of endotoxin. Treatments were administered in a 4 x 4 Latin square crossover design with 1-wk periods between challenges with endotoxin. Four individual treatments, control, ascorbic acid only, L-histidine only, and ascorbic acid plus L-histidine, were applied. Two doses of 25 g of ascorbic acid administered intravenously at 3- and 5-h postendotoxin challenge increased milk production recovery (9% higher, P < 0.02) and tended to reduce the extent of rumen stasis. Two doses of 25 g of L-histidine similarly administered decreased plasma antioxidant activities 5.5% (P < 0.05). However, ascorbic acid and L-histidine had no effects on rectal temperature, heart rate, respiratory rate, and dry matter intake. The data suggested that ascorbic acid provided some potential benefit for recovery from acute mammary inflammation in dairy cattle.

Novel Feed Including Olive Oil Mill Wastewater Bioactive Compounds Enhanced the Redox Status of Lambs

“…For example, common diseases such as pneumonia (15), enteritis (16) and septicemia in pigs (17) are caused by disorders in antioxidant homeostasis. The administration of antioxidants can protect animals from these diseases or reduce their clinical symptoms (18). In addition, studies have shown that animals at an early age have a low antioxidant system compared to adults (19,20), and so it is more important to administer antioxidants to young animals for disease protection.…”

Plasma Vitamin C Concentration is Not Related to the Incidence of Ketosis in Dairy Cows during the Early Lactation Period

“…A recent study indicated that plasma vitamin C level was decreased after the induction of mastitis in lactating cows [19]. Furthermore, vitamin C administration stimulated recovery from acute mammary inflammation in dairy cattle [4]. These reports suggested that stressed cattle possibly suffered from vitamin C deficiency.…”

Avaliação De Estresse Oxidativo No Plasma De Bovinos Leiteiros Com Mastite

“…Diante disso, sugere-se que esses animais poderiam receber uma dieta suplementada com ASA, já que a mesma não é produzida de forma endógena e a fim de auxiliar no tratamento preservando o status oxidativo de vacas leiteiras quando elas se encontram em condições promotoras da síntese de ERs no organismo, minimizando assim a ocorrência de efeitos adversos em virtude do estresse oxidativo (40,41) . Cabe salientar que Chaiyotwittayakun et al (42) investigaram o efeito da administração de ácido ascórbico após induzir a inflamação da glândula mamária em vacas e evidenciaram que duas doses de 25 g administradas por via intravenosa em três e cinco horas após indução do processo inflamatório aumentam a recuperação da produção de leite em 9%, o que confirma a nossa indicação de suplementação de ASA no tratamento da mastite bovina.…”