The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats

Sönmez, Mustafa; Türk, Gaffari; Yüce, Abdurrauf

doi:10.1016/j.theriogenology.2004.10.003

Cited by 333 publications

(200 citation statements)

References 30 publications

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“…24 Conversely, ascorbate administration to normal animals stimulates both sperm production and testosterone secretion. 27 This vitamin also counteracts the testicular oxidative stress induced by exposure to pro-oxidants such as arsenic, PCBs (Arochlor 1254), cadmium, endosulfan and alcohol. [28][29][30][31][32] Furthermore, endogenous ascorbate levels decrease dramatically when oxidative stress is induced in the testes by, for example, chronic exposure to lead, chromium, cadmium or aflatoxin.…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

Antioxidant Systems and Oxidative Stress in the Testes

Aitken

Roman

2009

Advances in Experimental Medicine and Biology

159

105

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Section: Antioxidant Enzymesmentioning

confidence: 99%

Antioxidant Systems and Oxidative Stress in the Testes

Aitken

Roman

2009

Advances in Experimental Medicine and Biology

159

105

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“…(7), ascorbic acid deficiency caused deterioration in the reproductive performance of guinea pigs. Sönmez et al (40) suggest that ascorbic acid supplementation improves reproductive traits of male rats, which is associated with high fertility. In the available literature, there is little data on the effect of vitamin C on these processes in boars.…”

Section: Variability Of Semen In Boars Treated With Vitamin C In Foodmentioning

confidence: 99%

Variability of semen in boars treated with vitamin C in food ration

Lechowski¹,

Kasprzyk²,

Trawińska³

2018

Medycyna Weterynaryjna

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The main criterion for keeping a boar at an insemination station is the production of boar ejaculates containing a high quantity of spermatozoa with a high fertilization potential. The production of boar semen is affected by the biological value of the boar (22,44) and by environmental factors (4, 46). As far as the biological value is concerned, the breed of the boar is considered to be of paramount importance (17,36,39,45) as it has critical influence on most semen traits. The age of the animal also plays a role (20,32,38,44). Among the environmental factors, the most important are the rearing conditions coupled with an appropriate nutrition strategy. Currently, boars of sire breeds (lines) selected for commercial use as AI sires are subjected to reproductive, fattening and slaughter evaluation.Recently, there have been reports of problems related to the deterioration of boar reproductive traits, such as reduced sexual activity and poor semen quality (2,18,19,35). There could be many reasons for that, e.g. excessive physiological burden associated with the fast growth rate resulting from intensive selection based on fattening and slaughter traits. The process of spermatogenesis can be affected deleteriously by other environmental factors, such as pesticides, exogenous female hormones and heavy metals, while positive effects may come from feed supplementation with, among others, carnitine, arginine, selenium and vitamin E. Administration of vitamins B12, B6 and PP contributes to increased sperm cell counts and improves their motility (23). Importantly, the effectiveness of

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“…The percentage of forward progressive sperm motility was assessed using a light microscope with heated stage as described by Sonmez et al (18).…”

Section: Evaluation Of Sperm Parametersmentioning

confidence: 99%

Antioxidant effects of ellagic acid on testicular tissue of rats exposed to tobacco smoke

Kaya¹,

Ozan²,

Dabak³

et al. 2017

J Turgut Ozal Med Cent

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Aim: Tobacco smoke negatively affects the male reproductive system. Ellagic acid (EA) has protective effects against oxidative damage. The aim of the study was to examine the protective effects of EA on testis of rats exposed to tobacco smoke. Material and Methods: Twenty-four male Spraque-Dawley rats were divided into 4 groups (n=6): Control, tobacco smoke (TS), tobacco smoke+corn oil (TS+C) and tobacco smoke+ EA (TS+EA). TS, TS+C and TS+EA groups were exposed to tobacco smoke 1 hour twice a day and EA was applied 12 mg/kg every other day. Testis tissues were removed. eNOS immunohistochemical stain and TUNEL methods were applied. Biochemical analyzes and sperm analyzes were performed. Results: Degeneration in germinative epithelium, cell debris in the seminiferous tubule lumen, seperation in basement membrane, atrophic tubules, vascular congestion and edema in interstitial area were observed in TS and TS+C groups. Increased apoptotic cells and eNOS immunreactivity were observed in TS and TS+C groups. EA administration caused a decrease in histological alterations, eNOS immunreactivity and apoptotic cells. Increased MDA levels, decreased CAT and GSH-Px activities were observed in TS and TS+C groups. MDA levels decreased, CAT and GSH-Px activities increased in TS+EA group. A significant increase in the amount of abnormal sperm was detected in TS and TS+C groups. The reduction in the amount of abnormal sperm was detected in TS+EA group. Conclusions: Exposure to TS led to marked alterations on testes tissue and treatment with EA might prevent these toxic effects.

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The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats

Cited by 333 publications

References 30 publications

Antioxidant Systems and Oxidative Stress in the Testes

Antioxidant Systems and Oxidative Stress in the Testes

Variability of semen in boars treated with vitamin C in food ration

Antioxidant effects of ellagic acid on testicular tissue of rats exposed to tobacco smoke

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