The effect of arsenic trioxide on brain monoamine metabolism and locomotor activity of mice

Itoh, Takeshi; Zhang, Yi Fei; Murai, S.; Saito, Hiroko; Nagahama, Hiromichi; Miyate, Hiroki; Saito, Yuichi; Abe, Eiichi

doi:10.1016/0378-4274(90)90202-w

Cited by 90 publications

(18 citation statements)

References 14 publications

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“…Although developmental exposure to arsenic can produce cognitive deficits in humans, most of the neurobehavioral studies with animal models have focused on locomotor activity (Bardullas et al 2009; Rodriguez et al 2002; Rodriguez et al 2001; Schultz et al 2002; Itoh et al 1990; Pryor et al 1983). However, when comparing six animal studies that report such changes, no two studies used the same dose range or replicated even a single dose if issues of route of administration and exposure duration are considered.…”

Section: Introductionmentioning

confidence: 99%

“…However, when comparing six animal studies that report such changes, no two studies used the same dose range or replicated even a single dose if issues of route of administration and exposure duration are considered. Three of these studies observed hypoactivity in rats as dose increased (Schultz et al 2002; Rodriguez et al 2001; Pryor et al 1983), one study noted hyperactivity in rats (Rodriguez et al 2002), while two studies reported dose-specific hyper- or hypoactivity in mice (Bardullas et al 2009; Itoh et al 1990). …”

Section: Introductionmentioning

confidence: 99%

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Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice

Markowski

Reeve

Onos

et al. 2012

Neurotoxicology and Teratology

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Consumption of arsenic-contaminated drinking water is associated with numerous cancers and dermal and vascular diseases. Arsenic is also a potent nervous system toxicant and epidemiological studies indicate that intellectual functions in children are compromised following early developmental exposure. This study was designed to examine the effects of arsenic on a broad range of age-specific behaviors including basic sensory-motor responses in neonates, locomotor activity and grip strength in juveniles, and operant measures of learning and attention in adults. Pregnant C57BL6/J mice consumed drinking water containing 0, 8, 25, or 80 ppm sodium arsenite from the fourth day of gestation until birth. Arsenic produced a range of behavioral impairments in male and female offspring at each of the test ages. The most striking effects of arsenic were on the development of gait and other motor responses including acoustic startle, righting reflexes, and forelimb grip. These results suggest that developmental arsenic exposure can produce other behavioral impairments in children in addition to cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice

Markowski

Reeve

Onos

et al. 2012

Neurotoxicology and Teratology

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“…Neurologic tests have shown nerve axonophathy and demyelination (Franzblau and Lilis 1989; Rodriguez et al 2003; Yung 1984). As also affects the content of brain monoamines, and the concentrations of dopamine and serotonin in the hippocampus, hypothalamus, cerebral cortex, and the striatum (Itoh et al 1990; Mejía et al 1997; Rodríguez et al 2003). …”

mentioning

confidence: 99%

Arsenic Exposure and Cognitive Performance in Mexican Schoolchildren

Rosado

Ronquillo

Kordas

et al. 2007

Environ Health Perspect

320

196

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BackgroundPrevious studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans.ObjectiveOur goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age children.MethodsWe recruited 602 children 6–8 years of age living within 3.5 km of a metallurgic smelter complex in the city of Torreón, Mexico, to participate in a cross-sectional evaluation. Of these, 591 had complete anthropometry, iron, and zinc status by biochemical measurements in serum, blood lead concentration (PbB), and arsenic in urine (UAs), and 557 completed several cognitive performance tests.ResultsThe mean for UAs was 58.1 ± 33.2 μg/L; 52% of the children had UAs concentrations > 50 μg/L, and 50.7% of children had PbB ≥10 μg/dL. UAs concentration was associated with low socioeconomic status. Nutritional status indicators were not related to UAs concentrations. Linear and logistic regressions adjusted for hemoglobin concentration, PbB, and sociodemographic confounders showed a significant inverse association between UAs and Visual–Spatial Abilities with Figure Design, the Peabody Picture Vocabulary Test, the WISC-RM Digit Span subscale, Visual Search, and Letter Sequencing Tests (p < 0.05). Boys excreted significantly more UAs (p < 0.05) and were affected on different cognitive areas than girls.ConclusionsChildren living in an area contaminated with both As and lead showed that As contamination can affect children’s cognitive development, independent of any effect of lead.

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“…Rodriguez et al [59] were reported the diminished level of DA, HVA and DOPAC in the corpus striatum of rats after the exposure to mining waste containing mainly arsenic. Hyper-locomotor activity at a low dose (3 mg/kg body weight) and while decreased motor activity in those treated with a high dose of arsenic trioxide (10 mg/kg body weight) was observed in mice [60].…”

Section: Discussionmentioning

confidence: 99%

“…Overproduction of DA can lead to hyperactivity and linked with attention deficit hyperactivity disorder [56]. Weaned mice received to arsenic (20,40,60 or 100 ppm) showed a significant correlation between arsenic level and regional monoamine levels in the brain and also found the ACTH levels in plasma were significantly associated with NE concentration in pons and medulla (Delgado et al 2000). Declined levels of DA while an increase in the levels of NE and 5-HT were reported in the whole brain of guinea pigs after the exposure to arsenic (25 mg/l) for 120 days [57].…”

Section: Discussionmentioning

confidence: 99%

Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

Chandravanshi¹,

Patel²

2017

J Environ Anal Toxicol

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The effect of arsenic trioxide on brain monoamine metabolism and locomotor activity of mice

Cited by 90 publications

References 14 publications

Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice

Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice

Arsenic Exposure and Cognitive Performance in Mexican Schoolchildren

Subchronic Early Life Arsenic Exposure at Low Doses Impaired the Biogenic Amine Neurotransmitter and Nitric Oxide Levels in Different Brain Regions of Rats

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