The effect of Aronia consumption on lipid profile, blood pressure, and biomarkers of inflammation: A systematic review and meta‐analysis of randomized controlled trials

Abstract

Plant derivatives, such as anthocyanin-rich phytochemicals, have been reported to elicit a positive effect on lipid profile. Therefore, the aim of this study was to systematically review and meta-analyze the effects of Aronia consumption on lipid profiles, blood pressure, and biomarkers of inflammation in randomized controlled trials.A systematic search was performed in PubMed/MEDLINE, Cochrane, and SCOPUS up to December 2018. Seven studies were identified and analyzed in this metaanalysis. Our study found a significant increase in high-density lipoprotein (HDL; weighted mean difference [WMD]: 1.48 mg/dl, 95% confidence interval, CI, [1.29, 1.68]) and diastolic blood pressure (WMD: 2.55 mmHg, 95% CI [0.63, 4.47]) following Aronia consumption. There was no significant effect on systolic blood pressure and C-reactive protein, tumor necrosis factor, and interleukin-1. Furthermore, subgroup analysis showed that cholesterol (WMD: −7.18, 95% CI [−13.90, −0.46]) and lowdensity lipoprotein (LDL; WMD: −5.84, 95% CI [−6.91, −4.77]) decreased more significantly in interventions less than 10 weeks in duration. Dose-response analysis demonstrated a significant reduction in triglyceride levels when dose of Aronia was increased to 300 mg/day. In conclusion, the results demonstrated a significant increase in HDL and reduction in total cholesterol and LDL among patients supplementing with Aronia.

Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells

“…The potential anti-inflammatory effects of aronia fruit extract or juice have been widely reported [ 20 , 21 , 22 , 23 ]. Aronia fruit extract has been shown to dose-dependently inhibit NO production in LPS-stimulated Raw 264.7 cells [ 24 , 25 ].…”

Biomarkers of geroprotection and cardiovascular health: An overview of omics studies and established clinical biomarkers in the context of diet

“…Another frequent observation is that berry-based interventions were effective only above a certain dosage and in studies of sufficient duration. Rahmani et al (2019) reported a decrease in TAGs only for doses higher than 300 mg/day, Fallah, Sarmast, and Jafari (2020) reported more significant decreases in FBG, 2-h PPG, HbA1c, and HOMA-IR for studies that had a duration of eight weeks or more and dosages higher than 300 mg/day, Daneshzad et al ( 2019) reported significant decreases in TC and LDL only for doses of anthocyanins higher than 300 mg/day and durations of 12 weeks or more, reported that doses of anthocyanins higher than 300 mg/day are more effective at decreasing the levels of CRP, IL-6, TNF-α, and VCAM-1, and Yang et al (2017) reported stronger reductions in HbA1c and TAGs levels with doses of anthocyanins higher than 400 mg/d. Most of the reviews we investigated did not focus on any single berr y but covered various berries, anthocyanin-rich foods, and extracts.…”

Composition, polyphenol bioavailability, and health benefits of aronia berry: a review

“…diabetes and aronia extract for adolescents with metabolic syndrome have also been promising for modulating serum lipids and reducing oxidative stress and inflammation biomarkers. A systematic review and meta-analysis of literature concluded that among human interventions, aronia consumption leads to increases in HDL and diastolic blood pressure (Rahmani et al, 2019). Thus, further trials are needed to strengthen the evidence base for the specific populations that benefit from aronia berry consumption.…”