The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats

Feng, Jinghui; Zhao, Hang; Du, Mengze; Wu, Xiuping

doi:10.1016/j.peptides.2019.03.006

Cited by 25 publications

(26 citation statements)

References 51 publications

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“…In a situation of chronic FA overload, the inhibition of CD36 [ 10 , 23 , 265 ], or CD36-deficient [ 256 ] reduced FA uptake, leads to the promotion of glucose uptake and glycolysis, the reduction of FA oxidation, lipid accumulation, and ROS generation, thereby protecting cardiomyocytes from lipotoxicity and oxidative stress. Such endogenous substances as fibroblast growth factor 21 (FGF21) [ 266 ] and a newly identified adipokine apelin [ 267 ] limit DM-induced increase in CD36 expression, thereby reducing FA uptake and metabolism. These effects translate into the function of the heart.…”

Section: The Role Of Cd36 In Diabetic Complicationsmentioning

confidence: 99%

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

Puchałowicz

Rać

2020

Cells

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CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy.

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Section: The Role Of Cd36 In Diabetic Complicationsmentioning

confidence: 99%

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

Puchałowicz

Rać

2020

Cells

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“…7,8 One study reported that treatment with apelin 13 for 10 weeks in type 2 diabetic rats prevented the destruction of pancreatic beta cells, thereby increasing serum insulin levels and decreasing hyperglycemia. 9 Today, due to the lack of complete treatment of diabetes with synthetic drugs, the tendency to use natural compounds has increased; medicinal herbs have a significant role in the treatment of diabetic patients because of their low side effects, their availability and their effectiveness. 10 Curcumin, dipropyl methane, is a hydrophobic polyphenol derived from the rhizome of Curcuma longa.…”

Section: Introductionmentioning

confidence: 99%

<p>Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats</p>

Shamsi-Goushki¹,

Mortazavi²,

Mirshekar³

et al. 2020

DMSO

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Background and Purpose: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and abnormalities in insulin production. Apelin is associated with insulin resistance. According to the anti-diabetic properties of curcumin, the purpose of this study was to compare the effects of curcumin and nano-curcumin intake on insulin resistance and serum levels of fasting blood sugar (FBS), Apelin, and lipid profile (cholesterol, triglyceride, LDL, HDL and VLDL) in T2DM rats. Materials and Methods: Forty-eight male Wistar rats were divided into six groups: Control, diabetic, diabetic treated with two doses of curcumin (100 and 200 mg/kg) and diabetic treated with two doses of nano-curcumin (100 and 200 mg/kg). Induction of T2DM was performed by intraperitoneal injection of Nicotinamide (110 mg/kg) and Streptozotocin (45 mg/kg) in the fasting state. Rats received different doses of nano-curcumin and curcumin by gavage (daily) for 28 days. At the end of the intervention period, insulin resistance and serum levels of FBS, apelin and lipid profiles were measured. Results: Insulin resistance and serum levels of FBS, Apelin, cholesterol, triglycerides, LDL, and VLDL were significantly decreased in diabetic rats treated with curcumin and nanocurcumin (p<0.05) so that nano-curcumin in reducing lipid profile is more effective than curcumin (P<0.05). Serum level of HDL in nano-curcumin groups was significantly higher than diabetic and curcumin groups (p<0.05). Also, with increasing insulin resistance, serum level of apelin increased (P<0.05). Conclusion: The therapeutic effects of curcumin and nano-curcumin were effective in decreasing insulin resistance, serum levels of FBS, apelin and lipid profile. The dose of 100 mg/kg nano-curcumin was more effective in reducing lipid profile.

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“…In keeping with this, circulating insulin concentrations were returned to normal levels in pGlu(Lys 8 Glu‐PAL)apelin‐13 amide‐treated STZ mice, despite less obvious benefits on α‐ and β‐cell areas. Intriguingly, 10 weeks' daily injection of native apelin‐13 in STZ‐induced diabetic rats was recently reported to increase β‐cell mass 34 . This finding by Feng et al 34 is somewhat difficult to interpret, given that native apelin has a very short duration of biological action 35 .…”

Section: Discussionmentioning

confidence: 99%

“…Intriguingly, 10 weeks' daily injection of native apelin‐13 in STZ‐induced diabetic rats was recently reported to increase β‐cell mass 34 . This finding by Feng et al 34 is somewhat difficult to interpret, given that native apelin has a very short duration of biological action 35 . Such differences between the studies could be related to the duration of treatment, single as opposed to multiple low‐dose STZ diabetes induction methods, or the altered sensitivity to STZ between rats and mice 36 .…”

Section: Discussionmentioning

confidence: 99%

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

Tanday

Irwin

Moffett

et al. 2020

Diabetes Obesity Metabolism

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Aim: The current study has tested the hypothesis that the positive effects of apelin receptor activation in diabetes are linked to benefits on islet cell apoptosis, proliferation and transdifferentiation using Ins1 Cre/+ ;Rosa26-eYFP transgenic mice and induction of diabetes-like syndromes by streptozotocin (STZ) or high-fat feeding. Materials and methods: Groups (n = 6-8) of streptozotocin (STZ)-induced diabetic and high-fat diet (HFD)-fed mice received once-daily injection (25 nmol/kg) of the long-acting acylated apelin-13 analogue, pGlu(Lys 8 Glu-PAL)apelin-13 amide, for 10 or 12 days, respectively. Results: pGlu(Lys 8 Glu-PAL)apelin-13 amide treatment partly reversed body weight loss induced by STZ and normalized circulating insulin. There was no effect of pGlu(Lys 8 Glu-PAL)apelin-13 amide on these variables in HFD-fed mice, but an increase in pancreatic insulin content was observed. pGlu(Lys 8 Glu-PAL)apelin-13 amide also fully, or partially, reversed the detrimental effects of STZ and HFD on plasma and pancreatic glucagon concentrations. In HFD-fed mice, the apelin analogue decreased dietary-induced elevations of islet, βand α-cell areas, whilst reducing α-cell area in STZ-induced diabetic mice. In terms of islet cell lineage, pGlu(Lys 8 Glu-PAL)apelin-13 amide effectively reduced βto α-cell transdifferentiation and helped maintain β-cell identity, which was linked to elevated Pdx-1 expression. These islet effects were coupled with decreased β-cell apoptosis and α-cell proliferation in both models, and there was an accompanying increase of β-cell proliferation in STZ-induced diabetic mice. Conclusion: Taken together these data demonstrate, for the first time, that pancreatic islet benefits of sustained APJ receptor activation in diabetes are linked to favourable islet cell transition events, leading to maintenance of β-cell mass.

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The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats

Cited by 25 publications

References 51 publications

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring

<p>Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats</p>

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

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