The Effect of Aortic Coarctation on Expression of Endothelin-1 and Endothelin Receptors in Heart and Lungs

Sirviö, Marja-Leena; Uhlenius, Nina; Stewen, Pia; Metsärinne, Kaj; Fyhrquist, Frej

doi:10.3109/08037059509077614

Cited by 3 publications

(2 citation statements)

References 23 publications

(7 reference statements)

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“…Another explanation may be a vascular response to aortic coarctation, or to vascular injury, despite the success of the intervention. A study performed on rats with aortic coarctation demonstrated that production of endothelin-1 decreased, and endothelin receptors were down-regulated, in hypertrophied ventricles 8 weeks after the production of coarctation as a compensatory response to pressure overload 27 . Another study involving patients with cardiac failure showed that levels of atrial natriuretic peptide and endothelin-1 in the plasma after peak exercise are potentially more reliable and important than their resting levels as markers of left ventricular systolic dysfunctions 28 .…”

Section: Discussionmentioning

confidence: 99%

Myocardial performance after successful intervention for native aortic coarctation

et al. 2010

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Coarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood.

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Section: Discussionmentioning

confidence: 99%

Myocardial performance after successful intervention for native aortic coarctation

et al. 2010

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“…Some authors showed that the production of endothelin-1 increased in the hypertrophied left ventricle (26), but it depends on the time of the disease progress. Ventricular endothelin-1 levels and the density of endothelin-1 binding sites were increased significantly, without affecting their binding affinity, on day 8 of pressure overload (27), after then, the production of endothelin-1 is decreased and endothelin receptors are down-regulated in hypertrophied ventricles 8 weeks after aortic coarctation (28). However, it is also reported that endothelin-1 levels in subjects with heart failure in whom they are found to be elevated in the late, decompensated phase of the disease (29).…”

Section: Discussionmentioning

confidence: 99%

Myocardial Protective Effect of Tezosentan, an Endothelin Receptor Antagonist, for Ischemia-Reperfusion Injury in Experimental Heart Failure Models

et al. 2009

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The myocardial protective effects of endothelin antagonist in ischemic cardiomyopathy (ICMP), doxorubicin-induced cardiomyopathy (DOX) and pressure-overload hypertrophy by transverse aortic constriction (TAC) models have been predicted to be different. The objective of this experiment, therefore, is to evaluate the myocardial protective effect of tezosentan, an endothelin receptor antagonist, in various experimental heart failure models. Sprague-Dawley rats (6-8 weeks old, 200-300 g) were randomized to three experimental groups (n=30 each): ICMP; DOX; and TAC group. Each of these groups was randomly assigned further to the following subgroups (n=10 each): sham-operated ischemia-reperfusion subgroup (SHAM); tezosentan treated ischemia-reperfusion subgroup (Tezo); and tezosentan non-treated ischemia-reperfusion subgroup (N-Tezo). Total circulatory arrest was induced for 1 hr, followed by 2 hr of reperfusion. The left ventricular developed pressure, peak positive and negative first derivatives, and coronary blood flow were significantly different (P<0.05) among the SHAM, Tezo, and N-Tezo subgroups of the ICMP group at 30 min of reperfusion, but there were no statistically significant differences among the subgroups of the DOX and TAC groups. In conclusion, tezosentan, an endothelin receptor antagonist, showed myocardial protection effects only on the ischemic cardiomyopathy rat model, but not in the non-ischemic heart failure rat models.

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Endothelin Receptors

Henry¹,

Goldie²

2001

Endothelin and Its Inhibitors

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The Effect of Aortic Coarctation on Expression of Endothelin-1 and Endothelin Receptors in Heart and Lungs

Cited by 3 publications

References 23 publications

Myocardial performance after successful intervention for native aortic coarctation

Myocardial performance after successful intervention for native aortic coarctation

Myocardial Protective Effect of Tezosentan, an Endothelin Receptor Antagonist, for Ischemia-Reperfusion Injury in Experimental Heart Failure Models

Endothelin Receptors

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