The effect of antioxidants on <i>Helicobacter pylori</i> eradication: A systematic review with meta‐analysis

Yang-Ou, Yao-Bin; Hu, Yi; Zhu, Yin; Lü, Nonghua

doi:10.1111/hel.12535

Cited by 15 publications

(14 citation statements)

References 46 publications

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“…The mechanism of action of dietary antioxidant compounds on H. pylori is not clear. However, the intake of antioxidant-rich nutrients in animals with Helicobacter pylori has been shown to reduce both the number of bacteria in the gastric mucosa and the in ammatory process (8,20). On the other hand, it is possible that these cultivations, by destroying the Iklova factor, have direct antiseptic properties and prevent NF-κβ nuclear transfer, thereby reducing genetic expression and producing mediators associated with relevant in ammation such as TNF-α, IL-1β, IL-6 and IL-8.It is possible that antioxidant-rich nutrient, by controlling some of the toxins that cause enough bacteria to grow by creating special anionic channels in the plasma membrane associated with the release of bicarbonate and organic anions in gastric cells, they have a bene cial effect (30).…”

Section: Discussionmentioning

confidence: 99%

“…On other hand, Studies suggest that antioxidants (eg, vitamins and N-acetylcysteine) play a role in reducing active oxygen species and gastric in ammation caused by H. pylori, which also exacerbates the disease and prevents the growth of bacteria and eliminates bio lm formation (8). So far, numerous studies have shown that vitamin C and E levels are lower in people with Helicobacter pylori than in those without H. pylori (8). Thus, impaired antioxidant and anti-in ammatory defenses may cause or exacerbate a chronic condition of pyloric H infection.…”

Section: Introductionmentioning

confidence: 99%

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The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

Sohouli

Haghshenas

Fatahi

2020

Preprint

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Objective Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study. Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10–0.40; P for trend, < 0.001). Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

Sohouli

Haghshenas

Fatahi

2020

Preprint

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“…Our previous study showed that N‐acetylcysteine plays a protective role in H pylori ‐related diseases . We investigated the efficacy and safety of adding antioxidants to triple or quadruple therapy and showed that the addition of antioxidants to amoxicillin‐clarithromycin‐based therapy could improve the eradication rate . However, antioxidant supplements have no impact on improving side effects.…”

Section: Discussionmentioning

confidence: 99%

“…However, the efficacy of H pylori eradication has steadily declined, primarily because of antibiotic resistance . Our previous studies have shown that the addition of antioxidants, such as vitamins, N‐acetylcysteine, curcumin, and cranberry, to amoxicillin‐clarithromycin–based therapy could improve the eradication rate …”

Section: Antioxidants: a New Strategy For Helicobacter Pylori‐relatedmentioning

confidence: 99%

“…While the efficacy and safety of adding antioxidants to triple or quadruple therapies remains unclear, we performed a systematic review with meta‐analysis to investigate this therapy and showed that the addition of antioxidants to amoxicillin‐clarithromycin–based therapy could improve the eradication rate and that vitamin supplementation might be effective at a high dosage. However, antioxidant supplements have no impact on improving side effects . Oxidative stress results in DNA damage, which is the main pathogenic mechanism behind H pylori ‐related diseases.…”

Section: Antioxidants: a New Strategy For Helicobacter Pylori‐relatedmentioning

confidence: 99%

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A lucid review of Helicobacter pylori‐induced DNA damage in gastric cancer

Xie

2019

Helicobacter

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Helicobacter pylori (H pylori) is the main risk factor for gastric cancer (GC). In recent years, many studies have addressed the effects of H pylori itself and of H pylori-induced chronic inflammation on DNA damage. Unrepaired or inappropriately repaired DNA damage is one possible carcinogenic mechanism. We may conclude that H pylori-induced DNA damage is one of the carcinogenic mechanisms of GC. In this review, we summarize the interactions between H pylori and DNA damage and the effects of H pylori-induced DNA damage on GC. Then, focusing on oxidative stress, we introduce the application of antioxidants in GC. At the end of this review, we discuss the outlook for further research on H pylori-induced DNA damage. K E Y W O R D SDNA damage, Helicobacter pylori, NF-κB, PLK

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Helicobacter pylori in the post-antibiotics era: from virulence factors to new drug targets and therapeutic agents

Al-Fakhrany,

Elekhnawy

2023

Arch Microbiol

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Helicobacter pylori is considered one of the most prevalent human pathogenic microbes globally. It is the main cause of a number of gastrointestinal ailments, including peptic and duodenal ulcers, and gastric tumors with high mortality rates. Thus, eradication of H. pylori is necessary to prevent gastric cancer. Still, the rise in antibiotic resistance is the most important challenge for eradication strategies. Better consideration of H. pylori virulence factors, pathogenesis, and resistance is required for better eradication rates and, thus, prevention of gastrointestinal malignancy. This article is aimed to show the role of virulence factors of H. pylori. Some are involved in its survival in the harsh environment of the human gastric lumen, and others are related to pathogenesis and the infection process. Furthermore, this work has highlighted the recent advancement in H. pylori treatment, as well as antibiotic resistance as a main challenge in H. pylori eradication. Also, we tried to provide an updated summary of the evolving H. pylori control strategies and the potential alternative drugs to fight this lethal resistant pathogen. Recent studies have focused on evaluating the efficacy of alternative regimens (such as sequential, hybrid, concomitant treatment, vonoprazan (VPZ)-based triple therapy, high-dose PPI-amoxicillin dual therapy, probiotics augmented triple therapy, or in combination with BQT) in the effective eradication of H. pylori. Thus, innovating new anti-H. pylori drugs and establishing H. pylori databanks are upcoming necessities in the near future.

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The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta‐analysis

Cited by 15 publications

References 46 publications

The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

A lucid review of Helicobacter pylori‐induced DNA damage in gastric cancer

Helicobacter pylori in the post-antibiotics era: from virulence factors to new drug targets and therapeutic agents

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