The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?

Abstract

Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro- and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis.

Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema

“…In an overview of food, therapeutic and industrial applications of Brazilian fruits of Arecaceae family, de Souza et al considered açaí, from the physicochemical perspective, as a good supplement in the human diet due to its high content of compounds with known pharmacological properties and/or health benefits [ 35 ], such as oleic acid [ 36 ], anthocyanins [ 37 ], carotenoids [ 38 ] and phenolic compounds [ 39 ]. These compounds are related to the powerful antioxidant activity of berries [ 40 ] and other underused wild plants seeds [ 41 ] such as the acai seed.…”

A case of prurigo pigmentosa occurring in a patient with psoriasis vulgaris following a ketogenic diet during the COVID‐19 pandemic

“…To the best of our knowledge, this is the first case of PP induced by cytokines, interferon-c, interleukin-17, and tumor necrosis factor-a in various diseases, it has been suggested that ketogenic diets can be a therapeutic option for psoriasis. 2 Conversely, PP was provoked by ketogenic diet in our psoriasis patient. The pathogenesis of PP is still unclear.…”

Dietary Inflammatory Index in relation to psoriasis risk, cardiovascular risk factors, and clinical outcomes: a case-control study in psoriasis patients

“…Similarly, the anti-inflammatory effects of diet on psoriasis could be explained by beneficial mechanisms mainly exerted by a dietary component such as oleic acid, monounsaturated fatty acids, polyphenols, dietary fibers, anti-oxidant agents, and micronutrients (Katsimbri et al 2021). Additionally, a particular diet may change the gut microbiota and thus elicit unwanted and aggravated immune function (e.g., modification of the T helper cell, T-regulatory cell, and type 17 and its balance) which can activate systemic autoimmune diseases (Chow and Mazmanian 2009).…”