The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model

Shishido, Stephanie N.; Faulkner, Emma B.; Beck, Amanda P.; Nguyen, Thu Annelise

doi:10.1371/journal.pone.0064866

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…40 The antiapoptotic effect of survivin is connected with caspase-3 activation. 41 Survivin can directly inhibit the activity of caspase-3 downstream of the apoptotic pathway and indirectly inhibit the activation of caspase-3 by means of caspase-9. The homodimers of Bax could be increased on account of Bax strongly expressing; furthermore, Bax overexpression could alter mitochondrial transmembrane potential, activate caspase-7 and caspase-3 downstream, accomplish substrate excision, and accelerate apoptosis by combining with mitochondrial membrane, as well as initiating a cascade of caspase.…”

Section: Discussionmentioning

confidence: 99%

Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy

et al. 2020

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Sea cucumber is a kind of food. Holothurian glycosaminoglycan (hGAG) is extracted from the body wall of the sea cucumber. Administration of hGAG and cisplatin (DDP) together to treat lung cancer was investigated. Lung adenocarcinoma A549 cells were cultured and divided into 4 groups: control group, hGAG 100 µg/mL group, DDP 3 µg/mL group, and hGAG 100 µg/mL + DDP 3 µg/mL group. Cell inhibition and apoptosis was evaluated by CCK8 and Hoechst33258 staining. Cell cycle was tested by Annexin V-FITC/PI (propidium iodide) double-staining and flow cytometry. The expression of mRNA and protein of Bcl-2, Bax, caspase-3, and survivin were detected by reverse transcriptase-polymerase chain reaction and Western blot, respectively. The results showed that hGAG combined with DDP enhanced the inhibitory effect of DDP on A549 lung cells through apoptosis pathway. The mechanism of apoptosis may be related to the reduction of Bcl-2 and survivin, as well as the ascension of Bax and caspase-3. hGAG could promote A549 cell cycle arrest in G1 and G2 phase and improve the DDP chemotherapy effects on A549 cells.

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Section: Discussionmentioning

confidence: 99%

Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy

et al. 2020

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“…BC is a rare disease in men. It has been reported that 1% of BC diagnosed in the United State is found in men [30][31][32]. In the present study, the patients were subsequently divided into thirteen groups of age as follows: 29 to…”

Section: Sex and Age At Diagnosismentioning

confidence: 99%

Improving Invasive Breast Cancer Care Using Machine Learning Technology

Yedjou¹,

Tchounwou²,

Grigsby³

et al. 2022

J Biomed Res Environ Sci

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Breast Cancer (BC) is the most common malignancy in women worldwide. In the United States, the lifetime risk of developing an invasive form of breast cancer is 12.5% among women. BC arises in the lining cells (epithelium) of the ducts or lobules in the glandular tissue of the breast. The goal of the present study was to use Machine Learning (ML) as a novel technology to assess and compare the invasive forms of BC including, infiltrating ductal carcinoma, infiltrating lobular carcinoma, and mucinous carcinoma. To achieve this goal, we used ML algorithms and collected a dataset of 334 BC patients available at https://www.kaggle.com/amandam1/breastcancerdataset and interpreted this dataset based on the form of BC, age, sex, tumor stages, surgery type, and survival rate. Among the 334 patients, 70% were diagnosed with infiltrating ductal carcinoma, 27% with infiltrating lobular carcinoma, and 3% with mucinous carcinoma. Overall, out of 334 BC patients: 64 (19.16%) were in stage I, 189 (56.59%) in stage II, and 81 (24.25%) in stage III. Sixty-six, 67, 96, and 105 patients underwent lumpectomy, simple mastectomy, modified radical mastectomy, and other types of surgery, respectively. The survival rates were 83.4% for stage I, 79.1% for stage II, and 77% for stage III. Findings from the present study demonstrated that ML provides an important tool to curate large amount of BC data, as well as a scientific means to improve BC outcomes.

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Exploring the One Health Paradigm in Male Breast Cancer

Tay,

Cowan,

Chatterji

et al. 2024

J Mammary Gland Biol Neoplasia

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How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that encourages cross-pollination of medical research uniting human and veterinary medicine. Recognising that breast cancer occurs spontaneously in other male species (e.g. primates, canines, felines), and knowing that no laboratory models exist for male breast cancer, which limits our ability to perform functional studies, we explored the feasibility of applying One Health to breast cancer in men by conducting a narrative review of the topic. Spontaneous development of breast cancer was reported in captive male primates and in companion canines and felines. Some parallels in tumour biology of human male breast cancer with canines and primates were found. The age distribution, pattern of biomarker expression and metastasis were similar, with mammary tumours typically detected after two-thirds of average lifespan. However, instances of triple negative and inflammatory breast cancer, which are rarely observed in human male breast cancer, were found in canines and histological classification was inconsistent between species. These disparities need redressing to enable full exploration of the One Health paradigm in rare cancers.

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The Effect of Antineoplastic Drugs in a Male Spontaneous Mammary Tumor Model

Cited by 3 publications

References 50 publications

Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy

Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy

Improving Invasive Breast Cancer Care Using Machine Learning Technology

Exploring the One Health Paradigm in Male Breast Cancer

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