The Effect of Antimicrobial Peptide Conjugated PGCL Sutures on In Vitro Wound Healing

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

“…19,20 Although the presence of a surgical suture is crucial to enhance mechanical support in wound closure, they sharply decrease the needed number of bacteria for emerging an infection. 4,17,21 The suture materials are considered as foreign bodies that may cause inflammatory reactions and may affect negatively the wound-healing process. 22 Induction of the biofilm formation by surgical sutures is promoted by the attachment of planktonic form of microorganisms to the suture surfaces and the proliferation of this microorganism enhances the enlargement of biofilm which protects them from host defense responses.…”

“…12,13 A surgical suture is a natural/synthetic medical device that approximates the body tissues together by its mechanical support until the desired wound healing process is obtained without any zonal infection. [14][15][16][17] Several surgical sutures are available on the market such as catgut, poliglecaprone, polyglactin 910, poly (glycolic acid-cocaprolactone) (PGCL), polypropylene, polyester, and silk. 18,19 Among other sutures, poly (glycolic acid-cocaprolactone) (PGCL) consists 75% polyglycolic acid and 25% e-caprolactone and has a monofilament structure which enhances less bacterial colonization according to multifilament sutures.…”

“…[33][34][35][36] Antimicrobial Peptides (AMPs) are the molecules of all multicellular organisms that take place in the innate immune system as the first line of defense with broad-spectrum antimicrobial effects against Gram-positive and Gramnegative bacteria, fungi, and viruses. 17,37,38 AMPs not only take a part in the innate immune system but also modulate the host's inflammatory response during infection. 39 In addition, AMPs induce wound healing in the skin by enhancing cell proliferation, cell migration, some parts of angiogenesis, and regulation of cytokine production.…”