The Effect of Antilymphocyte Serum, Fractionated Donor Bone Marrow, and Cyclosporine on Renal Allograft Survival in Mongrel Dogs

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

“…This approach has been successful for feline and human patients for many years. In contrast, canine renal transplant is rarely performed in a clinical setting, primarily because of lack of an effective, safe, and affordable immunosuppressive protocol preventing long term graft rejection in unrelated dogs 1–24 …”

An Evaluation of Combined Immunosuppression with MNA 715 and Microemulsified Cyclosporine on Renal Allograft Rejection in Mismatched Mongrel Dogs

“…[6][7][8][9][10] Anti-thymocyte sera alone extended median survival slightly to 17 to 18 days; 6,11 the combination of ATS and cyclosporine (3.2 to 20 mg/kg/day) increased median survival to 22 to 35 days. 11 Median survival times for the oil-based formulation of cyclosporine alone are reported as 13 days (2.5 mg/kg/day), 12 9 days (5 mg/kg/day), 8 and 8 days (10 mg/kg/day) 9 ; for combinations of cyclosporine (20 mg/kg/day) and prednisone as 44 days; and for azathioprine and prednisone as 26 days. 13 Combining cyclsoporine (12.5 mg/kg/day) and azathioprine extended median survival to 68 days.…”

The Role of the Thymus in Tolerance

“…(193-195) Mechanistic studies performed in these models showed that allograft survival correlated with the presence of donor class II mRNA in the recipient’s thymus (196). Studies in canines by the Monaco group demonstrated that donor bone marrow infusion induced prolonged graft survival in a large animal model(197). When this strategy was applied in a primate model using an anti-CD3 immunotoxin and donor bone marrow, prolonged graft survival was again observed(198).…”