The Effect of Antibiotic Use Within the First Year of Life On 3-Year Childhood Obesity

Abstract

The aim of the present study was to research the effect of antibiotic use within first year of life on 3-year obesity or overweight condition in consideration of maternal obesity, birth weight, gender, the weight gained during pregnancy. Materials and Methods: This retrospective cohort study was conducted on 182 healthy children who were born in Rize (Turkey) province and followed regularly until 3 years of age. The antibiotics used by the children within first 12 months of their life were determined through electronic health cards and the association between antibiotic use and 3-year obesity or overweight status was detected. Results: We used logistic regression to adjust for potential confounders. In the crude analysis, risk of being overweighed and obesity was evaluated in the children who were exposed to antibiotic use within first 12 months of life in comparison within those who have not used. (odds ratio: 1.40; 95% CI: [ 1.23-1.57]). After multivariate adjustment, the increased risk remained (adjusted odds ratio: 1.22; 95% CI: [1.04-1.40]). Conclusion: The results obtained indicated that risk of obesity is significantly higher in the 3-year old children who were exposed to antibiotics within first 12 months of life. Further studies may focus on prevention of obesity in the children due to antibiotic use.

Impact of promoting healthy infant feeding practices on energy intake and anthropometric measures of children up to 6 years of age: A randomised controlled trial

“…Although the size of the effect for the difference between groups is small, these findings corroborate findings that early feeding practices may play a role in body composition in later life. [41][42][43] Furthermore, skinfold thickness and WC, in comparison to the other anthropometric measurements assessed, are better external indicators of the fat compartments related to metabolic and cardiovascular complications. 44 Moreover, children with central adiposity are at higher risk of chronic metabolic disease development.…”