The Effect of Antibacterial Agents on the Intestinal Flora of Patients: The Use of Aureomycin, Chloromycetin, Dihydrostreptomycin, Sulfasuxidine and Sulfathalidine*

Dearing, William H.; Heilman, Fordyce R.

doi:10.1016/s0016-5085(19)36589-8

Cited by 25 publications

(1 citation statement)

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“…Two possible mechanisms are responsible for the inhibition of Cundida colonization and dissemination from the alimentary tract: 1. decreasing the size of Cundidu population in the gut (50) and 2. inhibiting the mucosal association of Cundidu cells by forming thick layers of bacteria in the mucous material covering the epithelium (23). Pertinent to the first mechanism is the finding that antibiotic treatments suppress bacterial flora, thus permitting overgrowth of antimicrobial-resistant microorganisms including Cundidu (19,73). Kennedy and Voltz showed that hamsters treated with antibiotics had a high number of Cundidu colonizing their GI tracts with a raised incidence of dissemination to visceral organs (50).…”

Section: Role Of Normal Flora In the Protection Against Candida Infecmentioning

confidence: 99%

Mechanisms Potentiating Candida Infections. A Review

Ghannoum

1988

Mycoses

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Summary: Candida infection follows impairment of the host's normal defense systems which is brough about by a multitude of predisposing factors. These factors affect both the host and/or the yeast in such a manner that they make the host susceptible to infection. Protective mechanisms which are detrimentally affected in the host include defense systems, anatomical barriers and indigenous microbial flora. Alterations in the yeast include growth, morphology and adherence capabilities. It is impossible to place a priority on whether effects on the host defenses are more important than the effects on the yeast in making the host more suceptible to infection. It is felt that the mechanism potentiating Candida infection is rather a complex biological phenomenon in which both partners should be taken into consideration. Specific predisposing factors should be considered simultaneously. Zusammenfassung: Candida‐Infektionen treten als Folge einer Wirtsabwehrmonderung auf, die durch eine Vielzahl prädisponierender Faktoren hervorgerufen wird. Diese Faktoren betreffen den Wirt wie auch den Hefepilz in einer Weise, die den Wirt für die Infektion empfänglich macht. Schutzmechanismen des Wirtes, welche geschädigt sein können, sind das Abwehrsystem, anatomische Barrieren und die körpereigene Normalflora. Änderungen am Hefepilz betreffen das Wachstum, die Morphologie und die Adhärenzfähigkeiten. Es ist nicht leicht, zu entscheiden, ob Faktoren auf seiten des Wirtes oder auf seiten des Hefepilzes den Wirt für die Infektion empfänglicher machen. Offenbar sind die Mechanismen, welche der Candida‐Infektion den Weg bahnen, ein ziemlich komplexes biologisches Geschehen, bei dem beide Partner berücksichtigt werden müssen.

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