Abstract:Summary
The expression of TfR/CD71 in T‐cell surface plays a pivotal role in T‐cell activation and proliferation. Anti‐human‐TfR monoclonal antibody could be used as an immunosuppressant in transplant therapy because of their potential to suppress T‐cell responses to alloantigens. We therefore examined the feasibility of an anti‐human‐TfR chimeric antibody (D2C) in suppression of T‐cell activation in vitro and graft‐versus‐host reaction (GVHR) in animals. D2C is a chimeric antibody produced by introducing the … Show more
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