The Effect of Anti-NGF Receptor (p75 Neurotrophin Receptor) Antibodies on Nociceptive Behavior and Activation of Spinal Microglia in the Rat Brachial Plexus Avulsion Model

Matsuura, Yusuke; Iwakura, Nahoko; Ohtori, Seiji; Suzuki, Takane; Kuniyoshi, Kazuki; Murakami, Kenichi; Hiwatari, Ryo; Hashimoto, Ken; Okamoto, Seiji; Shibayama, Masataka; Kobayashi, Tomoko; Ogawa, Yoshitsugu; Sukegawa, Kouji; Takahashi, Kazuhisa

doi:10.1097/brs.0b013e318285ee20

Cited by 20 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All reviewed parameters are listed in Table . Table contains all publications included in the parameter analysis of this review and further indicates which parameters were analyzed in each publication (Abada, Schreiber, & Ellenbroek, ; Baiguera et al., ; Balkaya, Kröber, Gertz, Peruzzaro, & Endres, ; Cao et al., ; Cendelín, Voller, & Vozeh, ; Chen, Tsai, Lin, et al., ; Cheng et al., ; Cho, Nguyen, Satkunendrarajah, Branch, & Fehlings, ; Chuang et al., ; Côté, Detloff, Wade, Lemay, & Houlé, ; Deumens, Jaken, Marcus, & Joosten, ; Deumens et al., , ; Encarnacion et al., ; Ferdinandusse et al., ; Gabriel, Marcus, Walenkamp, & Joosten, ; Gensel et al., ; Hausner et al., ; Hetze, Römer, Teufelhart, Meisel, & Engel, ; Hill, Brodak, & Bartlett Bunge, ; Hilton et al., ; Hoffmann et al., ; Jeong et al., ; Lee, McKeon, & Bellamkonda, ; Lin et al., ; Matsuura et al., ; Mountney, Leung, Pedersen, Shear, & Tortella, ; Neumann et al., ; Petrosyan et al., ; Schira et al., ; Sheu et al., ; Singh, Murray, & Houle, ; Sucher et al., ; Truin et al., ; Vandeputte et al., ; Vlamings et al., ; Wang et al., , ; Westin, Janssen, Sager, & Temel, ; Yamamoto, Okui, Tatebe, Shinohara, & Hirata, ). Here 22 out of 42 analyzed papers showed high reliability and validity of at least one parameter measured by the catwalk.…”

Section: Resultsmentioning

confidence: 99%

“…All reviewed parameters are listed in Table 1. Table 2 contains all publications included in the parameter analysis of this review and further indicates which parameters were analyzed in each publication (Abada, Schreiber, & Ellenbroek, 2013;Baiguera et al, 2012;Balkaya, Kröber, Gertz, Peruzzaro, & Endres, 2013;Cao et al, 2008;Cendelín, Voller, & Vozeh, 2010;Chen, Tsai, Lin, et al, 2012b;Cheng et al, 1997;Cho, Nguyen, Satkunendrarajah, Branch, & Fehlings, 2012;Chuang et al, 2010;Côté, Detloff, Wade, Lemay, & Houlé, 2012;Deumens, Jaken, Marcus, & Joosten, 2007;Deumens et al, 2006Deumens et al, , 2013Encarnacion et al, 2011;Ferdinandusse et al, 2008;Gabriel, Marcus, Walenkamp, & Joosten, 2009;Gensel et al, 2006;Hausner et al, 2012;Hetze, Römer, Teufelhart, Meisel, & Engel, 2012;Hill, Brodak, & Bartlett Bunge, 2012;Hilton et al, 2013;Hoffmann et al, 2010;Jeong et al, 2011;Lee, McKeon, & Bellamkonda, 2010;Lin et al, 2010;Matsuura et al, 2013;Mountney, Leung, Pedersen, Shear, & Tortella, 2013;Neumann et al, 2009;Petrosyan et al, 2013;Schira et al, 2012;Sheu et al, 2012;Singh, Murray, & Houle, 2011;Sucher et al, 2010;…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small animal models

et al. 2017

View full text Add to dashboard Cite

IntroductionA range of behavioral testing paradigms have been developed for the research of central and peripheral nerve injuries with the help of small animal models. Following any nerve repair strategy, improved functional outcome may be the most important evidence of axon regeneration. A novel automated gait analysis system, the CatWalk™, can measure dynamic as well as static gait patterns of small animals. Of most interest in detecting functional recovery are in particular dynamic gait parameters, coordination measures, and the intensity of the animals paw prints. This article is designed to lead to a more efficient choice of CatWalk parameters in future studies concerning the functional evaluation of nerve regeneration and simultaneously add to better interstudy comparability.MethodsThe aims of the present paper are threefold: (1) to describe the functional method of CatWalk gait analysis, (2) to characterize different parameters acquired by CatWalk gait analysis, and to find the most frequently used parameters as well as (3) to compare their reliability and validity throughout the different studies.ResultsIn the reviewed articles, the most frequently used parameters were Swing Duration (30), Print Size (27), Stride Length (26), and Max Contact Area (24). Swing Duration was not only frequently used but was also the most reliable and valid parameter. Therefore, we hypothesize that Swing Duration constitutes an important parameter to be chosen for future studies, as it has the highest level of reliability and validity.ConclusionIn conclusion, CatWalk can be used as a complementary approach to other behavioral testing paradigms to assess clinically relevant behavioral benefits, with the main advantage that this system demonstrates both static and dynamic gait parameters at the same time. Due to limited reliability and validity of certain parameters, we recommend that only the most frequently assessed parameters should be used in the future.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small animal models

et al. 2017

View full text Add to dashboard Cite

show abstract

“…While some studies demonstrated a stress-related decrease of NGF mRNA expression in DRG or hippocampus (Nagano et al, 2003; Alfonso et al, 2004), others revealed an increase under such conditions (for review, see Miller, 2011). On the other hand, NGF has been shown to be a major contributor to the production of inflammatory hyperalgesia and maintenance of neuropathic pain (Matsuura et al, 2013). An increased expression has been observed in a CCI model of neuropathic pain (Nagano et al, 2003; Santos et al, 2012) and a single injection of NGF has been shown to induce hyperalgesia (Lewin et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Chronic Social Stress Time-Dependently Affects Neuropathic Pain-Related Cold Allodynia and Leads to Altered Expression of Spinal Biochemical Mediators

Coz

Genty

Anton

et al. 2017

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Clinical data have shown that chronic exposure to stress may be accompanied by an enhancement of inflammation-related pain sensitivity. In this context, little is however known on the impact of stress on neuropathic pain. In the present study we addressed this issue by combining the chronic constriction injury (CCI) model with an ongoing social stress (OSS) paradigm. Cold plate and von Frey tests were performed in 48 rats divided into four groups: OSS exposed to OSS, CCI subjected to chronic nerve constriction, OSS+CCI with a combination of neuropathy and stress and CON, a control group lacking any manipulation. While we did not observe any stress-related differences in mechanical sensitivity throughout the observation period, CCI rats were more sensitive to cold stimulation than OSS+CCI in the initial phase of neuropathy. A switch was observed at a later stage, leading to a hypersensitivity of the OSS+CCI compared to the CCI rats. At this time point we investigated the spinal mRNA expression of neuron and glia related molecules potentially involved in neuropathic pain and stress. The combination of psychosocial stress and neuropathic pain seemed to enhance glial cell activation, pro-inflammatory cytokine and neurotrophic factor mRNA levels, rather than glutamatergic transmission. Our data show that long lasting social stress may lead to time-dependent alteration of neuropathy-related cold pain sensitivity while mechanically-induced pain remains unchanged.

show abstract

“…The C7 nerve root contains 25000 myelinated fibers on average, which provides a rich dynamic source for reconstructing the functions of the whole injured brachial plexus [17][18]. Many studies have reported that the surgical method is demonstrated to achieve satisfactory clinical results and have no significant effect on the functions of the uninjured side [19][20].…”

Section: Discussionmentioning

confidence: 99%

A Clinical Analysis of Repairing the Whole Brachial Plexus Nerve Root Avulsion by Transferring C7 Nerve Root from the Uninjured Side

Wang¹,

Wang²

2019

AJCEM

View full text Add to dashboard Cite

Objective to perform a C7 transfer from the uninjured side for the patients with whole brachial plexus nerve root avulsion, conduct follow-up observations of the recovery conditions of the affected limb, and discuss the degree of the effect on the limb on the uninjured side and the mechanism. Method The 36 patients with whole brachial plexus nerve avulsion who received a C7 transfer from the uninjured side for repair by stages from January 2011-December 2011 in our hospital were selected as the objects to analyse the data of cases, carry out follow-up visits, evaluate of the limb functions on the uninjured side, and make comprehensive assessment in accordance with U.K. MRC scale for sensation and U.K. amended MRC scale for muscular strength. Result The follow-up visit results regarding the motor functions of the affected limb have indicated that there were 2 patients with effective recovery of supraspinatus muscular strength, 2 patients with effective recovery of deltoid muscular strength, 6 patients with effective recovery of biceps brachii muscular strength, 7 patients with effective recovery of triceps brachii muscular strength, 4 patients with effective recovery of extensor carpi muscular strength, and 5 patients with effective recovery of flexor carpi and flexor digitorum muscular strength. There were 7 patients whose latissimus dorsi muscular strength reached M5-, 7 patients whose triceps brachii muscular strength reached M5-, and 10 patients whose extensor digitorum muscular strength reached M5-6 months after operation. There were 3 patients whose limb on the uninjured side reached Sensation Grade S4, 12 patients whose limb on the uninjured side reached Sensation Grade S3+, 11 patients whose limb on the uninjured side reached Sensation Grade S3, and 10 patients whose limb on the uninjured side reached Sensation Grade S2 3 days after operation. The sensory functions of the majority of the patients recovered to S4 and their two-point discrimination approximately recovered to normal at the follow-up visit 1 year after operation. Conclusion Repair with C7 transfer from the uninjured side is currently an effective and feasible method to repair the functions of the affected limb in brachial plexus nerve root avulsion.

show abstract

The Effect of Anti-NGF Receptor (p75 Neurotrophin Receptor) Antibodies on Nociceptive Behavior and Activation of Spinal Microglia in the Rat Brachial Plexus Avulsion Model

Abstract: N/A.

Cited by 20 publications

References 32 publications

Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small animal models

Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small animal models

Chronic Social Stress Time-Dependently Affects Neuropathic Pain-Related Cold Allodynia and Leads to Altered Expression of Spinal Biochemical Mediators

A Clinical Analysis of Repairing the Whole Brachial Plexus Nerve Root Avulsion by Transferring C7 Nerve Root from the Uninjured Side

Contact Info

Product

Resources

About