The effect of anti-emetic drugs on rat embryonic heart activity

Ritchie, Helen E.; Huss, Isabelle Broström; Webster, William S.

doi:10.1016/j.reprotox.2019.06.002

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…Among them, diarrhea can be a self-limiting adverse side effect [ 8 ], while mammary gland hyperplasia with increased milk production and other disorders (e.g., lethargy, appetite loss, abdominal pain, and emesis) normally disappear after drug discontinuation [ 6 , 8 ]. The effect of domperidone on QT interval prolongation and possible cardiac toxicity has been extensively studied in human medicine [ 2 , 9 , 10 , 11 , 12 , 13 , 14 , 16 , 17 , 18 , 19 , 30 ], and the use of the drug has been restricted as a result by the European Medicines Agency in 2014 [ 28 ]. The possibility of a similar adverse effect in dogs has been previously pointed out [ 20 ], but it has not been investigated before this pilot study.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is reported that the drug can prolong the QT interval in the electrocardiographic (ECG) trace by blocking the rapid component of the delayed rectifier potassium current (IKr) through the human ether-a-go-related gene (hERG) ion channels, which are responsible for restoring membrane potential after each cardiac action potential [ 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…This experimental model demonstrates that domperidone can also prolong the QT interval by inhibiting cardiac Na + channels [ 15 ]. Potential cardiac adverse events due to the use of domperidone, with a delay in cardiac repolarization, have been reported in human medicine [ 9 , 10 , 11 , 12 , 13 , 14 ]. The risks of severe and potentially fatal cardiac arrythmias in association with domperidone are known in humans [ 16 ], particularly when administered at doses >30 mg/day [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Pilot Study on QTc Interval in Dogs Treated with Domperidone

Donato,

Caspanello,

De Majo

et al. 2024

Veterinary Sciences

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Domperidone is used as an immunomodulatory drug for Leishmania infantum infection and disease in dogs. However, a pro-arrhythmic side effect, caused by prolonged QT intervals, is reported in humans. This pilot study evaluated the corrected QT (QTc) interval in dogs treated with domperidone for preventive or therapeutic management of leishmaniosis. The electrocardiogram and blood concentration of creatinine, urea nitrogen, sodium, potassium, and chloride were evaluated seven days before the start and on the last day of therapy in 17 dogs receiving domperidone for four weeks. In two dogs, the QTc interval was measured before and 2 h, 3 h, and 12 h after administration of the drug on the first day of treatment. After treatment, QTc measures and chloride concentrations increased significantly, although the QTc value slightly exceeded the upper reference limit only in one dog, and chloride concentrations were always normal. Creatinine concentrations significantly decreased after therapy. In the two dogs monitored at different times on the first day of treatment, QTc values were always normal. Domperidone caused a slight prolongation of QTc interval, and further studies should be made for a risk assessment in dogs with cardiac diseases, electrolytic imbalance, and in those receiving drugs increasing QT interval or competing with domperidone metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pilot Study on QTc Interval in Dogs Treated with Domperidone

Donato,

Caspanello,

De Majo

et al. 2024

Veterinary Sciences

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“…Embryos were then randomly assigned to treatment or control group. Previous studies have shown that addition of 25 µM dimethyl sulfoxide (DMSO) does not significantly affect the embryonic HR (EHR) ( Ritchie et al, 2019 ). Each culture bottle with its single embryo was then administered 25 µL of test chemical (vinpocetine or apovincaminic acid at varying concentrations) or DMSO vehicle and then replaced in the incubator for an additional 1 h incubation.…”

Section: Methodsmentioning

confidence: 99%