The Effect of Anthocyanins on Blood Pressure

Abstract

The findings of clinical studies concerning the association between anthocyanins supplementation and blood pressure (BP) are inconsistent.In order to provide a more precise estimate of the overall effect of anthocyanins on systolic blood pressure (SBP) and diastolic blood pressure (DBP), we conducted a meta-analysis of clinical trials about anthocyanins supplementation and BP.PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure (CNKI) (until October 2015) were searched to identify potential studies with information on anthocyanins extract supplementation and arterial BP. The weighted mean difference (WMD) and 95% confidence interval (CI) were used as a summary statistic. Net changes in SBP and DBP between anthocyanins supplementation and placebo groups were calculated by subtracting the values at end of follow-up from those at baseline. Meta regression was used to explore the potential moderators of effect size. The publication bias was assessed using Begger's Funnel plots and Egger's tests; P < 0.05 was considered to be statistically significant.Finally, 6 clinical studies with 472 participants for the effect of anthocyanins consumption on BP were included in the present meta-analysis. There is no significant effect on either SBP (WMD: 1.15 mm Hg, 95% CI: −3.17 to 5.47, I2 = 56%) or DBP (WMD: 1.06 mm Hg, 95% CI: −0.71 to 2.83, I2 = 0%) following supplementation with anthocyanins.In summary, results from this meta-analysis do not favor any clinical efficacy of supplementation with anthocyanins in improving blood pressure. Further well-designed large randomized controlled trials (RCTs) with long follow-up period are needed to verify the association of anthocyanins supplementation and blood pressure.

Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability

“…Similar lowering effects on BP were reported with pomegranate juice (−4.96/−2.01 mmHg, SBP/DBP) [ 53 ]. On the other hand, grape (poly)phenols, green tea and cocoa had smaller effects on blood pressure than the present meta-analysis (−1.54/non-significant mmHg for grape seed extract [ 54 ]; −1.98/−1.92 mm Hg for green tea [ 55 ]; and non-significant/−1.60 mmHg for cocoa [ 56 ], SBP/DBP), and anthocyanins had no significant effects on blood pressure [ 57 ]. On blood lipids, no significant effects were reported for pomegranate juice and grape seed extract meta-analyses [ 54 , 58 ].…”

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

“…Also, the effects of tree nuts were shown to reduce T-C, LDL-Cand TAGs [23]. Regarding the ANC-containing products, a previous meta-analysis looking at the supplementation with blueberries and their effect on blood pressure concluded that the results were not convincing and that more RCTs were needed [19]. In the current meta-analysis, ANC-containing products have come out as quite consistent regulators of SBP and DBP.…”

“…Previous reviews and meta-analyses of randomized-controlled trials (RCTs) have explored the evidence of the effects of the intake of berry [16,17,18,19,20,21], nut [22,23], pomegranate [24,25], and grape [26,27] foods and (or) derived products on different cardiometabolic risk factors (i.e., serum lipids, blood pressure, glucose). The results of these analyses have indicated inconsistencies in the overall effects and have pointed at potential different responses between different subpopulations.…”

Dietary Polyphenol Intake, Blood Pressure, and Hypertension: A Systematic Review and Meta-Analysis of Observational Studies

“…However, meta-analysis of clinical trials on polyphenol supplementation showed contrasting results. A previous meta-analysis of randomized controlled trials on the effects of anthocyanins on blood pressure showed overall null results [65]. Other meta-analyses on soy isoflavones supplementation reported that soy isoflavone extracts significantly decreased systolic but not diastolic blood pressure in adult humans, and no dose–response relationship was observed [66], while another meta-analysis suggested that the effects were more evident in hypertensive, but not in normotensive individuals [67].…”