The Effect of Antenatal Steroid Therapy on Early Inflammation Markers and Leukocyte Counts in Premature Infants

Özmen, Esra Beşer; Şimşek, Gülsüm Kadıoğlu; Ceran, Burak; Canpolat, Fuat Emre; Kutman, Hayriye Gözde Kanmaz

doi:10.1080/15513815.2020.1792014

Cited by 1 publication

(2 citation statements)

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“…In a study on sheep, ACS administered 7 days before lipopolysaccharide suppressed inflammation in the brain 30 . Although this is controversial, several studies have found that ACS did not attenuate IL‐6 or other inflammatory markers 31,32 . We investigated cord IL‐6 levels to assess whether ACS influences cord blood S100B levels via its anti‐inflammatory effect.…”

Section: Introductionmentioning

confidence: 99%

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Antenatal corticosteroids‐to‐delivery interval associates cord blood S100B levels

Fuma

Kotani

Ushida

et al. 2023

J of Obstet and Gynaecol

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Aim: Antenatal corticosteroids (ACS) are recommended for women at risk of preterm birth before 34 weeks' gestation. However, adverse effects of ACS on the fetal brain have also been reported. The time interval from ACS administration to delivery (ACS-to-delivery interval) might alter the effect of ACS on the fetal brain. This study aimed to evaluate the effect of ACS-to-delivery interval on cord blood S100 calcium-binding protein B (S100B) levels as a biomarker of brain damage. Methods: Women who delivered between 2012 and 2020 at a tertiary medical center were divided into three groups according to ACS use and ACS-to-delivery interval, retrospectively: non-ACS, ACS ≤7 days, and ACS >7 days. Patients who did not complete the ACS regimen were excluded. The primary outcome was cord blood S100B levels. Results: Cord blood S100B levels were significantly lower in the ACS ≤7 days group than in the non-ACS and ACS >7 days groups. In the multiple regression analysis, birth ≤7 days after ACS showed a significant negative association with S100B level (p < 0.001). Conclusions: Reduced S100B levels were observed in infants born ≤7 days after ACS but not in infants born >7 days after ACS. These findings suggest the importance of ACS timing to optimize its effects on the fetal brain, although further studies are required to identify these mechanisms.

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Section: Introductionmentioning

confidence: 99%

“…30 Although this is controversial, several studies have found that ACS did not attenuate IL-6 or other inflammatory markers. 31,32 We investigated cord IL-6 levels to assess whether ACS influences cord blood S100B levels via its anti-inflammatory effect. (3) In sheep studies, ACS increased fetal blood glucose levels.…”

Section: Introductionmentioning

confidence: 99%