1997
DOI: 10.1097/00005392-199709000-00105
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The Effect of Angiotensin Converting Enzyme Inhibition and Angiotensin II Receptor Antagonism on Obstructed Rat Bladder

Abstract: In contrast to previous studies in neonatal rabbits, neither captopril nor losartan potassium significantly ameliorated the histological or biochemical features of partial bladder outlet obstruction in the rat. Further investigation is necessary into species specific differences to understand better the role that angiotensin II may have in mediating the bladder changes of experimentally induced obstruction.

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Cited by 2 publications
(4 citation statements)
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“…For example, Cheng et al (1997) demonstrated that the ACE inhibitor captopril partially reduced the increase in total DNA content and collagen production following urethral obstruction, and also mediated a mild reduction in total bladder weight in neonatal rabbits with bladder outlet obstruction. In female Sprague-Dawley rats, neither Persson et al (1996) nor Palmer et al (1997) were able to demonstrate that Ang II inhibition with losartan substantially prevented bladder hypertrophy. In contrast, telmisartan, which has a longer plasma half-life and slower receptor dissociation, was indeed able to attenuate bladder muscle hypertrophy (Yamada et al 2009).…”
Section: Local Renin-angiotensin Systemsmentioning
confidence: 90%
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“…For example, Cheng et al (1997) demonstrated that the ACE inhibitor captopril partially reduced the increase in total DNA content and collagen production following urethral obstruction, and also mediated a mild reduction in total bladder weight in neonatal rabbits with bladder outlet obstruction. In female Sprague-Dawley rats, neither Persson et al (1996) nor Palmer et al (1997) were able to demonstrate that Ang II inhibition with losartan substantially prevented bladder hypertrophy. In contrast, telmisartan, which has a longer plasma half-life and slower receptor dissociation, was indeed able to attenuate bladder muscle hypertrophy (Yamada et al 2009).…”
Section: Local Renin-angiotensin Systemsmentioning
confidence: 90%
“…Renin, a protease produced by renal juxtaglomerular cells, cleaves the Nterminus of angiotensinogen, forming angiotensin I (Ang I). Ang I is then converted to the octapeptide Ang II in the lungs (Palmer et al 1997;Cheng et al 1997)-via ACE. In addition, Ang I may be acted upon by chymase (a chymotrypsin-like serine protease released from mast cells) in an alternative catalysis pathway, producing Ang II.…”
Section: Synthesis Of Angiotensin IImentioning
confidence: 99%
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