The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation

Yuan, Yi; Wang, Xingran; Yan, Jiaqing; Li, Xiaoli

doi:10.1186/s12868-018-0476-2

Cited by 9 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amplitude and success rate of EMG decreased as the intensity of ultrasound decreased, as well as the response latency of EMG increased as the concentrations of anesthesia increased. Research on TUS has shown that as the depth of anesthesia increases, the success rate of EMG decreases and EMG response latency increases significantly (Yuan et al, 2018), and this study has shown that TMAS followed the same rule. Nevertheless, EMG amplitude induced by TMAS is higher and its EMG response latency is smaller than that induced by TUS under the same experimental conditions.…”

Section: Discussionsupporting

confidence: 58%

Comparative Study of Transcranial Magneto-Acoustic Stimulation and Transcranial Ultrasound Stimulation of Motor Cortex

Wang

Zhou

Cui

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Transcranial ultrasound stimulation (TUS; f < 1 MHz) is a promising approach to non-invasive brain stimulation. Transcranial magneto-acoustic stimulation (TMAS) is a technique of neuromodulation for regulating neuroelectric-activity utilizing a magnetic–acoustic coupling electric field generated by low-intensity ultrasound and magnetic fields. However, both techniques use the physical means of low-intensity ultrasound and can induce the response of the motor cortex. Therefore, it is necessary to distinguish the difference between the two techniques in the regulation of neural activity. This study is the first to quantify the amplitude and response latency of motor cortical electromyography (EMG) in mice induced by TMAS and TUS. The amplitude of EMG (2.73 ± 0.32 mV) induced by TMAS was significantly greater than that induced by TUS (2.22 ± 0.33 mV), and the EMG response latency induced by TMAS (101.25 ± 88.4 ms) was significantly lower than that induced by TUS (181.25 ± 158.4 ms). This shows that TMAS can shorten the response time of nerve activity and enhance the neuromodulation effect of TUS on the motor cortex. This provides a theoretical basis for revealing the physiological mechanisms of TMAS and the treatment of neuropsychiatric diseases using it.

show abstract

Section: Discussionsupporting

confidence: 58%

Comparative Study of Transcranial Magneto-Acoustic Stimulation and Transcranial Ultrasound Stimulation of Motor Cortex

Wang

Zhou

Cui

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Most of the previous studies conducted on anesthetized animals showed significant variability in the response to stimulation depending on the type and depth of anesthesia [73, 91]. To examine response to stimulation without the confounding effects from anesthesia, experiments in an awake setting are required, and several recent studies on non-human primates and human subjects have started to demonstrate the feasibility of FUS in brain stimulation without the use of anesthesia [33, 34, 37–43].…”

Section: Discussionmentioning

confidence: 99%

Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model

Yoon

Lee

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

Low-intensity focused ultrasound (FUS) has significant potential as a non-invasive brain stimulation modality and novel technique for functional brain mapping, particularly with its advantage of greater spatial selectivity and depth penetration compared to existing non-invasive brain stimulation techniques. As previous studies, primarily carried out in small animals, have demonstrated that sonication parameters affect the stimulation efficiency, further investigation in large animals is necessary to translate this technique into clinical practice. In the present study, we examined the effects of sonication parameters on the transient modification of excitability of cortical and thalamic areas in an ovine model. Guided by anatomical and functional neuroimaging data specific to each animal, 250 kHz FUS was transcranially applied to the primary sensorimotor area associated with the right hind limb and its thalamic projection in sheep (n = 10) across multiple sessions using various combinations of sonication parameters. The degree of effect from FUS was assessed through electrophysiological responses, through analysis of electromyogram and electroencephalographic somatosensory evoked potentials for evaluation of excitatory and suppressive effects, respectively. We found that the modulatory effects were transient and reversible, with specific sonication parameters outperforming others in modulating regional brain activity. Magnetic resonance imaging and histological analysis conducted at different time points after the final sonication session, as well as behavioral observations, showed that repeated exposure to FUS did not damage the underlying brain tissue. Our results suggest that FUS-mediated, non-invasive, region-specific bimodal neuromodulation can be safely achieved in an ovine model, indicating its potential for translation into human studies.

show abstract

“…Previous studies have demonstrated that enhancement or suppression of neural activity induced by TUS will be affected by the anesthesia dose. For instance, if the anesthesia dose is too high, the animal’s motion response and EEG signal of the motor cortex cannot be observed after ultrasound stimulation ( 18 – 20 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of low-intensity transcranial ultrasound stimulation on theta and gamma oscillations in the mouse hippocampal CA1

Chen

Liu

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

Previous studies have demonstrated that low-intensity transcranial ultrasound stimulation (TUS) can eliminate hippocampal neural activity. However, until now, it has remained unclear how ultrasound modulates theta and gamma oscillations in the hippocampus under different behavioral states. In this study, we used ultrasound to stimulate the CA1 in mice in anesthesia, awake and running states, and we simultaneously recorded the local field potential of the stimulation location. We analyzed the power spectrum, phase-amplitude coupling (PAC) of theta and gamma oscillations, and their relationship with ultrasound intensity. The results showed that (i) TUS significantly enhanced the absolute power of theta and gamma oscillations under anesthesia and in the awake state. (ii) The PAC strength between theta and gamma oscillations is significantly enhanced under the anesthesia and awake states but is weakened under the running state with TUS. (iii) Under anesthesia, the relative power of theta decreases and that of gamma increases as ultrasound intensity increases, and the result under the awake state is opposite that under the anesthesia state. (iv) The PAC index between theta and gamma increases as ultrasound intensity increases under the anesthesia and awake states. The above results demonstrate that TUS can modulate theta and gamma oscillations in the CA1 and that the modulation effect depends on behavioral states. Our study provides guidance for the application of ultrasound in modulating hippocampal function.

show abstract

The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation

Cited by 9 publications

References 30 publications

Comparative Study of Transcranial Magneto-Acoustic Stimulation and Transcranial Ultrasound Stimulation of Motor Cortex

Comparative Study of Transcranial Magneto-Acoustic Stimulation and Transcranial Ultrasound Stimulation of Motor Cortex

Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model

Effect of low-intensity transcranial ultrasound stimulation on theta and gamma oscillations in the mouse hippocampal CA1

Contact Info

Product

Resources

About