The effect of androgens and estrogens on induced prostatic tumor in the hamster

Abstract

The human adenovirus type 1 2 and the chcmical DMBA inoculated into the prostate of adult hamsters show tumorogenic affects only in the presence of exogcnous administration of estradiol or testosterone. The type of tumor observed was prostatic sarcoma, half of which were differentiated to fibrosarcoma. Castration did not change the incidence of the lesions. The pattern of hormonal influence was related to exogenous estrogen rather than androgen dependcncy when virus or DMBA were administered. Androgen dependency was found only in the presence of DMBA. Both stimuli together showed no potentiating effect in increasing prostatic tumor incidence.

A Status Report – Human Prostatic Carcinoma, with Emphasis on Potential for Viral Etiology

“…Varkarakis el al. [121], utilizing adult hamsters, found that introduction of human adenovirus type 12, and 7,12-dimethylbenzenthracene produced prostatic tumors, but only in the presence of exogenous estradiol or testosterone. Castration did not affect tumor production.…”