The Effect of an Oral Probiotic Containing Lactobacillus, Bifidobacterium, and Bacillus Species on the Vaginal Microbiota of Spayed Female Dogs

Hutchins, Rae G.; Bailey, C. Scott; Jacob, Megan E.; Harris, Tyler; Wood, Michael W.; Saker, Korinn E.; Vaden, Shelly L.

doi:10.1111/jvim.12174

Cited by 20 publications

(17 citation statements)

References 20 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One prospective controlled clinical study in dogs, however, demonstrated no benefit from orally administered Lactobacillus, Bifidobacterium and Bacillus species. 110 In cats, no clinical studies have, to date, provided data on the efficacy of this therapy.…”

Section: Preventive Therapymentioning

confidence: 99%

Urinary tract infection and subclinical bacteriuria in cats: A clinical update

Dorsch¹,

Teichmann-Knorrn²,

Lund

2019

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Practical relevance: Urinary tract infection (UTI) is an important cause of feline lower urinary tract disease (FLUTD), particularly in female cats older than 10 years of age. In addition to cats with typical clinical signs of FLUTD or upper UTI, many cats have subclinical bacteriuria, but the clinical relevance of this is currently uncertain. UTIs are one of the most important indications for antimicrobial use in veterinary medicine and contribute to the development of antimicrobial resistance. Adherence to treatment guidelines and confinement to a few first-line antimicrobial agents is imperative to avoid further deterioration of the antimicrobial resistance situation. The decision to treat with antimicrobials should be based on the presence of clinical signs, and/or concurrent diseases, and the results of urine culture and susceptibility testing. Clinical challenges: Distinguishing between cats with bacterial cystitis, and those with idiopathic cystitis and concurrent clinical or subclinical bacteriuria, is challenging, as clinical signs and urinalysis results may be identical. Optimal treatment of subclinical bacteriuria requires clarification as there is currently no evidence that demonstrates a beneficial effect of routine treatment. Management of recurrent UTIs remains a challenge as evidence for most alternatives used for prevention in cats is mainly anecdotal, and no preventive treatment modality is currently recommended. Evidence base: This review draws on an extensive literature base in veterinary and human medicine, including the recently updated guidelines of the International Society for Companion Animal Infectious Diseases for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Where published evidence is lacking, the authors describe their own approach; notably, for the bacteriuric cat with chronic kidney disease.

show abstract

Section: Preventive Therapymentioning

confidence: 99%

Urinary tract infection and subclinical bacteriuria in cats: A clinical update

Dorsch¹,

Teichmann-Knorrn²,

Lund

2019

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…Canine vaginal LAB have been found to exert antipathogenic activities thus have a probiotic potential [62] and could be used as strategies to combat urinary tract infections in dogs. One study evaluated oral administration of a commercial probiotic mixture containing lactobacilli (>64 bil CFU/g), bifidobacteria (30 bil CFU/g), and bacilli species (24 bil CFU/g), (strains not specified) along with a combination of yeast, enzymes, vitamins, and prebiotics, once daily for either 2 weeks or 4 weeks to 35 healthy bitches and found that probiotic mixture supplementation did not have an effect on the prevalence of vaginal LAB in studied animals [103].…”

Section: Probiotics and Urogenital Tract Infectionsmentioning

confidence: 99%

Microbiota and probiotics in canine and feline welfare

et al. 2015

View full text Add to dashboard Cite

Dogs and cats have been cohabiting with us for thousands of years. They are the major human companions. Today, dogs and cats live in urban areas. Cats and most dogs are on high carbohydrate diets and face similar life-style challenges as the human beings. The health and well-being of companion animals, just as their owners, depends on the gut microbes. Providing a proper care and nutritionally balanced diet to companion animals is recognised as a part of our responsibility to maintain the health and well being of our pet. However, as microbiota differences may facilitate exposure to pathogens and harmful environmental influences, it is prudent to search for novel tools to protect dogs and cats and at the same time the human owners from pathogens. Specific probiotic strains and/or their defined combinations may be useful in the canine and feline nutrition, therapy, and care. Probiotic supplementations have been successful in the prevention and treatment of acute gastroenteritis, treatment of IBD, and prevention of allergy in companion animals. New challenges for probiotic applications include maintenance of obesity and overweight, urogenital tract infections, Helicobacter gastritis and parasitic infections. The probiotics of human origin appear to be among the new promising tools for the maintenance of pets' health. However, the host-derived microorganisms might be the most appropriate probiotic source. Therefore, more controlled trials are needed to characterise new and safe probiotic preparations with an impact on general health and well being as well as health maintenance in dogs and cats.

show abstract

“…Our data coincide with the data of other authors. So, recently has been reported that strains of LAB, isolated from human or animal vagina or gut, have functional properties that can support their use as a potential probiotic for oral and vaginal applications [14,15,16]. These probiotic strains after oral application are able to colonize the vagina and effectively modulate vaginal microbiota and immunological profile.…”

Section: Table 2 the Cytokines Level In The Serum Of Infected Mice Thmentioning

confidence: 99%

Effects of Oral and Vaginal Administration of Probiotic Bacteria on the Vaginal Microbiota and Cytokines Production in the Case of Experimental Staphylococcosis in Mice

Лазаренко¹,

Бабенко²,

Mokrozub³

et al. 2017

Mikrobiol. Z.

View full text Add to dashboard Cite

Bifidobacterium animalis VKL-B. animalis VKB (Lc-VKL-VKB) or B. animalis VKL-B. animalis VKB (VKL-VKB) strain compositions that administrated both orally and vaginally or only orally, on the vaginal microbiota and cytokines production in experimental vaginal staphylococcosis in BALB/c mice. Methods. Probiotic bacteria administrated into staphylococcus-infected mice vaginally and orally simulntaneously or only orally. Material from the vagina was plated on selective media; the number of colony forming units was counted. The concentration of cytokines in the blood serum of mice was determined by enzyme immunoassay method. Results. It was found, that the number of aerobic and facultative anaerobic microorganisms in the vagina of staphylococcus-infected mice was decreased after administration of these probiotic bacteria or its compositions both into vagina and orally or only orally. The increase in the number of lactic acid bacteria (LAB) and bifidobacteria in the vagina of these mice was also observed. However, the number of coliform bacteria and microscopic fungi was smaller and the number of LAB was greater after administration of L. casei IMV B-7280 or Lc-VKL-VKB and VKL-VKB compositions into staphylococcus-infected mice vaginally and orally simultaneously, compared to only oral administration. A change of the vaginal microbiota of staphylococcus-infected mice that received these probiotic bacteria was accompanied with higher level of interferon-γ and interleukine-12 production, which favors the development of Th1 immune response and decrease of the production of pro-inflammatory cytokine tumor necrosis factor-α. The immunomodulatory effectiveness of L. casei IMV B-7280 and Lc-VKL-VKB composition will also be higher if they are administered into staphylococcus-infected mice both orally and vaginally than only orally. Conclusions. Probiotic strain L. casei IMV B-7280 and Lc-VKL-VKB or VKL-VKB strain compositions can be a good candidate for the creation of immunobiotics for treatment of urogenital infections.

show abstract

The Effect of an Oral Probiotic Containing Lactobacillus, Bifidobacterium, and Bacillus Species on the Vaginal Microbiota of Spayed Female Dogs

Cited by 20 publications

References 20 publications

Urinary tract infection and subclinical bacteriuria in cats: A clinical update

Urinary tract infection and subclinical bacteriuria in cats: A clinical update

Microbiota and probiotics in canine and feline welfare

Effects of Oral and Vaginal Administration of Probiotic Bacteria on the Vaginal Microbiota and Cytokines Production in the Case of Experimental Staphylococcosis in Mice

Contact Info

Product

Resources

About