The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study

Abstract

The use of an oral supplement containing glucosamine, minerals, and various antioxidant compounds can potentially improve the appearance of visible wrinkles and fine lines. It does not, however, affect epidermal hydration.

Photoaging: Mechanisms and repair

“…An oral supplement containing a combination of l-proline, l-lysine, manganese, copper, zinc, quercetin, grape seed extract, N-acetyl D-glucosamine, and glucosamine sulfate was shown to improve wrinkles by 34% in a pilot study when measured by optical profilometry. 136 Another oral supplement composed of a combination of vitamin E, vitamin C, carotenoid, selenium, and proanthocyanidin led to a significant decrease in induction of MMP after UV exposure. A reduction in UV-induced erythema was also noted, but it did not reach statistical significance.…”

Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy

“…Two short-term studies (Monauni et al, 2000;Pouwels et al, 2001) were reviewed to assess glucose metabolism. Four studies, one on skin wrinkles (Murad and Tabibian, 2001) and three on temporomandibular joint complaints (Nguyen et al, 2003;Shankland, 1998;Thie et al, 2001) were included to make the safety assessment as comprehensive as possible.…”

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

“…24 Collagen was added into the formula since experimental evidences from murine models has shown that: if adequately orally administered it prevents UV radiationinduced skin damage. 35,36 In a study by Proksch et al, oral supplementation of collagen hydrolysate composed of specific collagen peptides (2.5 g/d or 5.0 g/d for 8 weeks) increased skin elasticity in middle-aged women after 4 weeks of supplementation. 37 Previous studies confirmed that collagen hydrolysate is degraded to small peptides by the gastrointestinal tract, that appear later in the blood stream and reach the skin in 8 up to 96 hours.…”

“…44 Chondroitin sulfate is intrinsic factor of the biosynthesis of collagen and elastic fibres formation. 45 Previous studies showed that if integrated with other natural compounds, aminoacids, minerals, and various antioxidant compounds, it improves cutaneous aging-induced wrinkles 36 and stimulates hair follicles stem cells. 46 In fact, chondroitin sulfate binds and modulates the functions of a large number of biomolecules involved in hair follicle differentiation or proliferation, 47 including fibroblast growth factors (FGFs), 48 vascular endothelial growth factor (VEGF), 49 sonic hedgehog, 50 bone morphogenetic proteins (BMPs), 51 Wnt 50 and hepatocyte growth factor (HGF).…”