The Effect of an Intravenous Infusion of Rifamycin SV on the Excretion of Bilirubin, Bromsulphalein, and Indocyanine Green in Man

Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport

“…The same dose inhibited the biliary elimination of both 20 mg unconjugated bilirubin and of 20 mg conjugated bilirubin and elevated the serum concentration of the bile pigments in rats (Acocella and Billing 1969). This study, together with a previous one in man (Acocella et al 1965) led to the hypothesis that rifamycin SV, bilirubin, BSP, and indocyanine share a common biliary excretory mechanism. The authors supposed that the interaction is mainly at the canalicular level, and that rifamycin SV only partially interferes, if at all, with the hepatic uptake of other cholephilic organic anions.…”

Biliary excretion of antibiotics in man.

“…Decrease in bilirubin concentration was observed in connexion with the administration of rifamycin SV and rifamide. For rifamycin SV the hypothesis of a process of competition for excretion between the two substances has been put forward in studies carried out in animals and in man (Acocella and Billing, 1965;Acocella, Nicolis, and Tenconi, 1965). The reduction of bilirubin excretion could therefore be interpreted on the same basis.…”

Effect of rifampicin on liver function in man

“…For theoretical reasons, the similarity of the rifampicin molecule with that of the rifamycins leads one to expect that rifampicin might cause competition phenomena in the liver cell with other organic anions, such as bromsulphalein (BSP) or bilirubin (Acocella and Billing, 1965;Acocella, Nicolis, and Tenconi, 1965). ' Received for publication 8 February 1972. The purpose of the present study was to compare two groups of patients, the first receiving a single dose of rifampicin, in whom eventual competition was looked for, the other receiving the drug for 17 days, the main liver tests being kept under regular observation.…”