BACKGROUND
Background: Depressive symptoms are common in Veterans, and the presence of these symptoms increases disability and suicidal thoughts and behaviors. There is, however, evidence that these symptoms often go untreated. Intervening before symptoms are severe and entrenched is related to better long-term outcomes, including improved functioning and less disease chronicity. Computer-delivered interventions may be especially appropriate for those Veterans with mild-moderate depressive symptoms, as these interventions can require fewer resources and have lower barriers to access, and thus have potential for wider reach. Despite this potential, there is a dearth of research examining computerized interventions for depressive symptoms in Veteran samples.
OBJECTIVE
Objective: The aim of this study is to evaluate the efficacy of Deprexis, a computerized intervention for depressive symptoms and related functional impairment.
METHODS
Methods: First, qualitative interviews will be completed with a small subset of Veterans (n=16-20) to assess acceptability of procedures. Then, Veterans (n=132) with mild-moderate depressive symptoms will be randomly assigned to the Deprexis intervention or a treatment-as-usual control group. Primary outcomes will be depressive symptoms and various dimensions of psychosocial functioning.
RESULTS
Results: Recruitment is expected to begin in April 2024, with initial results expected in April 2029.
CONCLUSIONS
Conclusion: This study will provide initial evidence for the efficacy of self-guided computerized interventions for depressive symptoms and functional impairment in Veterans. If effective, these types of interventions could improve treatment access to psychosocial interventions for Veterans receiving care in the VA.
CLINICALTRIAL
ClinicalTrials.gov ID: NCT06217198