The effect of an infusion of low molecular weight dextran on peripheral resistance in patients with arteriosclerosis

Abstract

Low molecular weight dextran is frequently given to improve the flow of blood to the periphery, but its mode of action is uncertain. We measured the effect of an infusion of 500 ml of Dextran 40 on the peripheral resistance in 12 patients undergoing reconstructive surgery for atherosclerotic occlusion of the superficial femoral artery. After the infusion, values of packed cell volume and blood viscosity indicated haemodilution. There was a consistent increase in mean flow and a fall in peripheral resistance. There was no correlation between change in viscosity and change in peripheral resistance, but there was a good correlation between the percentage change in resistance and the initial resistance. This suggests that the increase in flow of blood was due to reflex vasodilatation rather than to any reduction in viscosity.

THE EFFECT OF ASPIRIN AND PROSTAGLANDINE1ON THE PATENCY OF MICROVASCULAR ANASTOMOSIS IN THE RATS

“…15 Low molecular weight dextran (an antiplatelet agent), is supposed to increase the blood flow, decrease the viscosity of the serum, and also have a thrombolytic effect. 9 A derivative of phenothiazinethioxanthene, chlorpromazine, is an anti-psychotic drug that prohibits vasoconstriction and stimulates the autonomous nervous system for vasodilation. 3,8 Aspirin is well known for its antiplatelet effect and thromboxane-A 2 synthesis inhibition.…”