Abstract:ABSTRACT. To evaluate the effect of an elevation in systemic arterial pressure upon pulmonary blood flow and arterial oxygenation during right ventricular hypertension (RVH), we acutely studied 13 1-d-old piglets. Catheters were positioned in the pulmonary artery, both atria, and the aorta for hemodynamic measurements. An electromagnetic probe was positioned in the main pulmonary artery for pulmonary blood flow measurement. Systemic and regional blood flow were measured with the radiolabeled microsphere techni… Show more
“…14 In newborn piglets with right ventricular hypertension, an elevation in systemic arterial pressure reduced right to left foramen ovale shunt and increased pulmonary blood flow and systemic oxygen delivery. 17 Our results are consistent with these studies, suggesting that the norepinephrine-induced raise in AoP may be associated with increased pulmonary blood flow. A pulmonary vasodilator response to norepinephrine was observed after acute hypoxia in isolated perfused cat lung, 18 and in isolated intra-pulmonary arteries of neonatal and adult pigs.…”
The data suggest that norepinephrine may improve post-natal pulmonary adaptation in the newborn with persistent PH both by increasing systemic vascular pressure and by increasing pulmonary blood flow.
“…14 In newborn piglets with right ventricular hypertension, an elevation in systemic arterial pressure reduced right to left foramen ovale shunt and increased pulmonary blood flow and systemic oxygen delivery. 17 Our results are consistent with these studies, suggesting that the norepinephrine-induced raise in AoP may be associated with increased pulmonary blood flow. A pulmonary vasodilator response to norepinephrine was observed after acute hypoxia in isolated perfused cat lung, 18 and in isolated intra-pulmonary arteries of neonatal and adult pigs.…”
The data suggest that norepinephrine may improve post-natal pulmonary adaptation in the newborn with persistent PH both by increasing systemic vascular pressure and by increasing pulmonary blood flow.
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