The effect of an angiotensin-converting enzyme inhibitor on water and electrolyte balance in water-restricted sheep

Abstract

The importance of angiotensin II in the regulation of water and electrolyte balance in sheep is questionable. In this trial the effects of an angiotensin-converting enzyme (ACE) inhibitor were quantified in sheep on restricted water intake. Comparing the phase of water restriction only with that of water restriction plus ACE inhibition, significant increases were observed during the latter phase in urine volume, sodium and potassium excretion <em>via</em> the urine, sodium concentration in the plasma and osmolar clearance. Urine osmolarity decreased with inhibition of angiotensin II formation while variables such as water, sodium and potassium loss <em>via</em> the faeces were unaffected. Most of the renal effects of ACE inhibition, except the increase in urinary potassium excretion, were explicable in terms of the established functions of angiotensin II. Furthermore, results of this trial indicate that angiotensin II has no significant effect on the intestine in regulating water and electrolyte excretion <em>via</em> the faeces

17β-Estradiol deficiency reduces potassium excretion in an angiotensin type 1 receptor-dependent manner

“…The finding that both an inhibitor of Ang II synthesis and an AT 1 R antagonist prevented the ovariectomy-induced decrease in the FE K+ supports this hypothesis. Furthermore, previous studies have shown that blocking AT 1 Rs or inhibiting Ang II action decreases plasma potassium by increasing potassium excretion (2,15,20).…”

Effect of Water Restriction and Rehydration on Haemato-Biochemical, Enzymatic and Hormonal Activity of Hoggets during Summer Season

“…The significant (p < 0.05) increase in serum urea concentration in the experimental animals under 40% water restriction is attributed to haematic concentration of metabolites that leads to the inability of the kidney to perform its function (Casamassima et al, 2016). It may also partially be related with increase in secretion of hormone angiotensin and vasopressin which are released from neurohypophysis in response to dehydration and increase permeability of collecting ducts of kidneys and thereby promote urea reabsorption in the kidneys and reduce loss of urea concentration (Meintjes and Engelbrecht, 1999). In earlier studies also, the water deprivation was associated with significant (p < 0.05) increase in serum urea concentration (Alamer, 2006;Hamadeh et al, 2006;Abdelatif et al, 2010;Gupta, 2013;Khanvilkar et al 2017 b ).…”

Impact of Water Deprivation and Rehydration on Blood Parameters of Sheep under Middle Gujarat Agro-Climatic Condition

“…collecting duct of kidneys and there by promote urea reabsorption in the kidneys and reduced the loss of urea concentration (Meintjes and Engelbrecht, 1999). The cortisol could be a good indicator in accessing acute stress response in small ruminants but not chronic stress such as dehydration, also reported that, cortisol level did not return to normal level even after 72 hours of rehydration (El-Nouty et al, 1991).…”