The Effect of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive functioning. The effect of improved nutrition, particularly with dietary supplements, on cognitive functioning may offer an alternative strategy compared to standard treatment. The present pilot study investigated the effect of an aloe polymannose multinutrient complex (APMC) formula on cognitive and immune functioning over 12 months among adults diagnosed with AD. Subjects participated in an open-label trial and consumed 4 teaspoons per day of the APMC. The ADAS-cog, MMSE, ADCS-ADL, and SIB were administered at baseline and 3, 6, 9, and 12 months follow-up. Cytokines and lymphocyte and monocyte subsets were assessed at baseline and 12 months. The mean ADAS-cog cognition score significantly improved at 9 and 12 months from baseline, and 46% of our sample showed clinically-significant improvement (≥4-point change) from baseline to 12 months. Participants showed significant decreases in tumor necrosis factor-α, vascular endothelial growth factor, and interleukins-2 and-4. CD90+, CD95+CD3+, CD95+CD34+, CD95+CD90+, CD14+CD34+, CD14+CD90+, and CD14+CD95+ decreased significantly, whereas CD14+ significantly increased. Participants tolerated the APMC supplement with few, temporary adverse reactions. Our results showed improvements in both clinical and physiological outcomes for a disease that otherwise has no standard ameliorative remedy.

Putative Prophylaxes of Aloe Vera for Age-Related Diseases

“…Participants tolerated the APMC supplement with few, temporary adverse reactions. The present results showed improvements in both preliminary clinical and physiological outcomes for a decrease that otherwise has no standard ameliorative remedy [62] .…”

A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging in healthy adults

“…Presumably, the wider array of nutrients in the fish, such as its vitamins and trace elements, produced its superior results. We previously showed improvements in cognitive and immune functioning and inflammation in persons with Alzheimer's disease in response to a dietary supplement containing multiple nutrients, such as polysaccharides, antioxidants, and omega-3 fatty acids, among others [19]. We also found that the combination of gingko biloba and choline produced modest improvements in cognitive functioning and inflammation in a sample of healthy elderly adults [20].…”

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

“…Participants tolerated the APMC supplement with few, temporary adverse reactions. The results showed improvements in both clinical and physiological outcomes for disease that otherwise has no standard ameliorative remedy [73] .…”