The effect of alternating and biphasic currents on humans' wound healing: a literature review

Martínez-Rodríguez, Alicia; Bello, Olalla; Fraiz, Manuel; Martínez-Bustelo, Sandra

doi:10.1111/j.1365-4632.2012.05836.x

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…Specifically, electrical stimulation has been shown to substantially improve healing and regeneration of chronic injuries, often achieving complete closure of wounds that had failed to respond to other treatments [15,16,17,18]. At the tissue level, it has been reported that electrical stimulation can improve blood flow [19], increase elasticity of damaged tissues [20,21] and reduce oedema [21].…”

Section: Introductionmentioning

confidence: 99%

Electric Stimulation at 448 kHz Promotes Proliferation of Human Mesenchymal Stem Cells

Hernández-Bule¹,

Paı́no²,

Trillo³

et al. 2014

Cell Physiol Biochem

108

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Background/Aims: Capacitive-resistive electric transfer (CRET) is a non invasive electrothermal therapy that applies electric currents within the 400 kHz - 450 kHz frequency range to the treatment of musculoskeletal lesions. Evidence exists that electric currents and electric or magnetic fields can influence proliferative and/or differentiating processes involved in tissue regeneration. This work investigates proliferative responses potentially underlying CRET effects on tissue repair. Methods: XTT assay, flow cytometry, immunofluorescence and Western Blot analyses were conducted to asses viability, proliferation and differentiation of adipose-derived stem cells (ADSC) from healthy donors, after short, repeated (5 m On/4 h Off) in vitro stimulation with a 448-kHz electric signal currently used in CRET therapy, applied at a subthermal dose of 50 μA/mm²Results: The treatment induced PCNA and ERK1/2 upregulation, together with significant increases in the fractions of ADSC undergoing cycle phases S, G₂ and M, and enhanced cell proliferation rate. This proliferative effect did not compromise the multipotential ability of ADSC for subsequent adipogenic, chondrogenic or osteogenic differentiation. Conclusions: These data identify cellular and molecular phenomena potentially underlying the response to CRET and indicate that CRET-induced lesion repair could be mediated by stimulation of the proliferation of stem cells present in the injured tissues.

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Section: Introductionmentioning

confidence: 99%

Electric Stimulation at 448 kHz Promotes Proliferation of Human Mesenchymal Stem Cells

Hernández-Bule¹,

Paı́no²,

Trillo³

et al. 2014

Cell Physiol Biochem

108

View full text Add to dashboard Cite

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“…Further, there is a lack of well-designed studies on biphasic and alternating stimulation and there is a need for improving the description of the parameters and in the uniformity of the nomenclature used. 58,59 Platelet-rich plasma As stated earlier, bacterial infection makes pressure ulcers difficult to heal. Clinically, platelet-rich plasma (PRP) assists in eliminating ulcers by acting as an antibacterial agent 60 thereby significantly reducing infection rates.…”

Section: Electrical Stimulationmentioning

confidence: 98%

“…Although different types of currents, including bidirectional currents, have been used to promote healing, there is neither a good analysis of their effects, nor a consensus on the best parameters to use to promote healing. Further, there is a lack of well‐designed studies on biphasic and alternating stimulation and there is a need for improving the description of the parameters and in the uniformity of the nomenclature used …”

Section: Newer Treatments For Pressure Ulcersmentioning

confidence: 99%

Improving the ability to eliminate wounds and pressure ulcers

Kuffler

2015

Wound Repair Regeneration

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Pressure ulcers can be initiated by as little as 2 hours of constant pressure on the ski, that blocks blood circulation causing the skin and underlying tissues to die, leading to an open wound that never heals, but continues to grow in diameter and depth, and frequently jeopardizes patients' lives. Despite the application of many diverse techniques, pressure ulcers remain exceptionally difficult to heal because many ulcer elimination techniques have minimal effects, and although other techniques may appear to be effective, the evidence supporting their efficacy is weak. However, increasing evidence indicates that other techniques, such as the application of platelet-rich plasma, vacuum assisted closure, electrical stimulation, and hyperbaric oxygen therapy are effective and should be substituted for the older techniques. This review describes different standard and novel techniques that have been tested for eliminating pressure ulcers and discusses the relative efficacy of these techniques.

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“…NMES devices deliver either a biphasic pulsed current or an alternating current: Such currents are described as bidirectional, in which reverse polarity occurs. 19 TENS also delivers a biphasic pulsed current. 19,20 In contrast, HVPC and LIDC employ unidirectional currents (direct current or monophasic pulsed currents), in which constant polarity occurs.…”

Section: Neuromuscular Electrical Stimulationmentioning

confidence: 99%

A Narrative Review of the Use of Neuromuscular Electrical Stimulation in Individuals With Diabetic Foot Ulceration

Goodall

Langridge

Lane

et al. 2020

The International Journal of Lower Extremity Wounds

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This review aims to summarize the evidence reported on the use of neuromuscular electrical stimulation (NMES) in individuals with diabetic foot ulceration (DFU). A systematic search of EMBASE and MEDLINE databases was performed in February 2019, using search terms relating to the domains DFU and NMES. All primary evidence assessing outcomes of NMES in DFU were included. Of 344 references obtained from database searching, 7 met the inclusion criteria and included a total of 140 participants, 77 of whom had DFU. All included studies used prospective designs. Two studies demonstrated improvements in chronic ulcer healing with NMES use; however, in each study, only 3 of the included participants had DFU and subgroup analyses based on ulcer etiology was omitted. The remaining 5 studies were produced by the same research group and positive effects of NMES (in combination with heat therapy) on DFU healing were consistently demonstrated. They reported significantly better healing rates with NMES in DFU than in nondiabetic wounds of a similar grade (healing rate: 70.0 ± 32.3% in DFU vs 38.4 ± 22.3% in nondiabetic ulcers [ P < .01]). These studies did not provide data assessing the isolated effects of NMES without concomitant heat exposure. Data on device tolerability and compliance were lacking. The existing data support a potential role for NMES in individuals with DFU; however, the identified studies inadequately controlled for confounding and were underpowered. Given the significant morbidity and mortality associated with DFU, higher quality evidence is needed to assess the adjunctive role for NMES in this group.

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The effect of alternating and biphasic currents on humans' wound healing: a literature review

Cited by 11 publications

References 32 publications

Electric Stimulation at 448 kHz Promotes Proliferation of Human Mesenchymal Stem Cells

Electric Stimulation at 448 kHz Promotes Proliferation of Human Mesenchymal Stem Cells

Improving the ability to eliminate wounds and pressure ulcers

A Narrative Review of the Use of Neuromuscular Electrical Stimulation in Individuals With Diabetic Foot Ulceration

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