The effect of Aloe vera powder on anthropometric and metabolic syndrome’s indices in patients with type 2 diabetes: a randomized, double-blinded controlled clinical trial

Abstract

Purpose It is well accepted that diabetes is associated with heart diseases and hyperlipidemia as a risk factor. In traditional medicines, some herbs such as Aloe vera seem to be effective in controlling diabetes. Owing to lack of human studies, this study aims to examine the effect of Aloe vera consumption on fasting blood sugar (FBS), lipid profiles and body composition in type 2 diabetic patients. Design/methodology/approach This double-blind, placebo-controlled trial study was conducted in 2019, in Shiraz, Iran. A total of 56 diabetic subjects were randomized by block randomization to receive a daily supplement of 1,000 mg Aloe vera powder capsules (n = 28) or placebo (n = 28) for eight weeks. At baseline and after eight weeks of treatment, dietary intake and physical activity were assessed by three-day food recall and international physical activity questionnaire. Meanwhile, after an overnight fasting, FBS and lipid profiles were measured. Blood pressure and anthropometric parameters were assessed in the beginning and the end of the study. Independent t-tests were used for between-group analysis and paired t-tests for within-group analysis. Findings After intervention, weight, body mass index and waist circumference significantly decreased in comparison to the placebo group (p-value: < 0.001, 0.001 and 0.02). Although, FBS, total triglyceride and systolic blood pressure decreased significantly (p-value: 0.03, 0.001 and 0.01), no change has been seen in low density lipoprotein, high density lipoprotein and total cholesterol blood level and diastolic blood pressure. Research limitations/implications The limitations of this study are the short study duration and lack of Aloe vera powder’s ingredient analysis. Originality/value This study is one of few human studies investigating the effect of Aloe vera on metabolic syndrome’s indices in diabetic patients. Because pharmacological therapy is tough, not comfort and correlated with potential adverse drug interactions, it is important to find an alternative or complementary measure to aid the diabetic patients. This study shows that Aloe vera has positive effect on body weight and blood sugar.

The effect of aloe vera syrup on the components of metabolic syndrome in patients with bipolar disorder type 1

“…Dosage and formulation of aloe vera products and duration of the study may affect on the results. In comparison with some studies 11,13,23 that had signi cant effects on indices, the lack of signi cant changes in our study may have been due to the different dose and form of aloe vera. Moreover, in our study, although medicines had not signi cant differences in two groups but medicines related to MetS were considered qualitatively no quantitatively.…”

“…In our study aloe vera syrup had not signi cant effect on blood pressure but Choudhary et al showed that Aloe vera L. gel powder signi cantly reduced blood pressure, blood glucose and lipid pro le 24 . However, in previous studies the effect of aloe vera on blood pressure was contradictory 23,25 .…”

“…In contrast to our results, Choi et al observed that aloe vera gel complex can reduce weight signi cantly after 8 weeks but did not decrease FBS signi cantly 12 . Also Zareian et al showed that daily consumption of 1000 mg Aloe vera powder reduced weight, BMI, waist circumference, FBS, TG and systolic blood pressure but did not change HDL, LDL, TC and diastolic blood pressure 23 . In our study aloe vera syrup had not signi cant effect on blood pressure but Choudhary et al showed that Aloe vera L. gel powder signi cantly reduced blood pressure, blood glucose and lipid pro le 24 .…”