The Effect of Alendronate on Bone Mineral Density in the Distal Part of the Femur and Proximal Part of the Tibia After Total Knee Arthroplasty

The effect of simvastatin on polyethylene particle-induced osteolysis

“…Utilizing this model, we showed that the third-generation bisphosphonate zoledronate can significantly decrease particleinduced bone resorption [15]. These findings are supported by recent clinical studies which report beneficial effects of bisphosphonate in improving fixation and durability of total joint replacements in humans [16,17].…”

Bisphosphonates for periprosthetic bone loss after joint arthroplasty: a meta-analysis of 14 randomized controlled trials

“…Eighteen trials were not RCTs nor had BMD data available, leaving 27 eligible trials. Three trials [11,12,14] carried a longer follow-up and re-analyzed data reported previously [20][21][22][23][24]. Two trials [9,25] seemed to report on a shared group of participants which was confirmed through contact with the first author.…”

Lower Total Knee Arthroplasty Revision Risk Associated With Bisphosphonate Use, Even in Patients With Normal Bone Density

“…Decreased risk of TKA revision with BPs may involve enhanced bone mineral density of supporting bone and improved implant fixation. Improved periprosthetic bone mineral density was observed with BPs after TKA in randomized control trials [15][16][17] and with meta-analysis [18]. Altering bone turnover, with reduction of osteoclast activity, may be one way in which BPs may potentially improve the fixation of implants to bone.…”