The Effect of Alcohol, Tobacco, and Aspirin Consumption on Seminal Quality among Healthy Young Men

Stutz, G.; Zamudio, Javier; Santillán, María Emilia; Vincenti, L.; Cúneo, Marta Fiol de; Ruiz, Rubén Daniel

doi:10.1080/00039890409603432

Cited by 45 publications

(32 citation statements)

References 25 publications

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“…However, generally the results of studies concerning the association between smoking and male reproductive parameters are contradictory. Some studies have shown a negative effect of smoking on semen parameters (Shen et al, 1997;Stutz et al, 2004;Pasqualotto et al, 2006) whereas others could not demonstrate such an effect (Vogt et al, 1986;Saaranen et al, 1987;Lewin et al, 1991;Pacifici et al, 1993). Furthermore, it has not been clarified whether smoking has an impact on levels of male reproductive hormones.…”

Section: Introductionmentioning

confidence: 99%

Association between tobacco exposure and reproductive parameters in adolescent males

et al. 2007

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Cigarette smoking is quite prevalent in the general population but our knowledge of its effect on male reproductive function is still very limited. Therefore, we investigated the impact of tobacco exposure on reproductive characteristics in young males. Military conscripts, 217 non-smokers and 85 smokers, with a median age of 18 years were enrolled. Physical examination and semen analysis, including measurement of accessory sex gland markers and reproductive hormone levels, were performed. Lifestyle-associated factors, including maternal smoking during pregnancy and snuffing, were recorded. Non-smokers had 49% higher total sperm number than smokers (95% CI 4.5-112%, p = 0.01). In addition, sperm concentration was 37% higher among non-smokers (95% CI -4% to 95%, p = 0.08). Serum levels of follicle-stimulating hormone (FSH) were 17% higher among non-smokers (95% CI 3-33%, p = 0.02), whereas no significant differences between smokers and non-smokers were found for inhibin B, testosterone, sex hormone binding globulin, luteinizing hormone and oestradiol. Those who smoked >10 cigarettes per day exhibited 37% lower (95% CI 10-69%, p = 0.005) FSH levels than those who smoked less. Maternal smoking during pregnancy had a negative impact on epididymal and seminal vesicle marker secretion. Smoking seems to impair sperm production and epididymal as well as accessory sex gland function and could be one of the factors contributing to regional differences in sperm parameters.

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Section: Introductionmentioning

confidence: 99%

Association between tobacco exposure and reproductive parameters in adolescent males

et al. 2007

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“…Similarly, alcohol users among 34 healthy Argentine medical students had a non-significant reduction in sperm concentration, motility, viability and normal morphology. 27 On the Alcohol and male fertility S La Vignera et al 222 other hand, a significantly lower percentage of morphologically normal spermatozoa in daily-drinkers (17.6%67.2%) compared with subfertile patients (23%66.5%) was reported. 26 Semen volume, sperm count, motility and the percentage of morphologically normal spermatozoa were reported to be significantly decreased in 66 nonsmoking and drug-free alcoholics who consumed a minimum of 180 ml alcohol per day (brandy and whisky, both 40%-50% alcohol content) for a minimum of 5 days per week for o1 year.…”

Section: 15mentioning

confidence: 99%

Does alcohol have any effect on male reproductive function? A review of literature

Vignera¹,

Condorelli²,

Balercia³

et al. 2012

Asian J Androl

140

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Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

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“…In a study of 12 male athletes, a 10‐day course of aspirin treatment was associated with a borderline significant increase in plasma testosterone but no change in DHEAS or free testosterone 22 . In contrast, an observational study of 34 healthy young men reported no association between aspirin use and plasma testosterone 23 . In a study of five sedentary men, treatment with a single 400‐mg dose of propyphenazone was associated with decreased urinary excretion of several testosterone metabolites, but no association was observed for treatment with other NSAIDs 24 .…”

Section: Discussionmentioning

confidence: 94%

Non steroidal anti‐inflammatory drug use and levels of oestrogens and androgens in men

Gates¹,

Araujo²,

Hall³

et al. 2012

Clinical Endocrinology

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Objective Studies suggest that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) may lower estrogen levels in women. However, no large, population-based studies have assessed NSAID/hormone associations in men. Our objective was to examine the association between use of prescription and over-the-counter NSAIDs and levels of estrogens and androgens in men. Design The Boston Area Community Health Survey, an observational survey with initial data collection in 2002–2005. Patients 1,766 men who provided a blood sample and data on recent analgesic use. Measurements Adjusted geometric mean levels of androgens, estrogens, SHBG, LH, and FSH for each category of NSAID use and the percent difference in hormone levels for users vs. non-users. Results There was no significant association between prescription or over-the-counter NSAID use and any hormone examined after adjustment for potential confounders. For example, geometric mean testosterone levels were 13.8, 13.6, and 14.2 nmol/L in non-users, prescription, and over-the-counter NSAID users, respectively; the corresponding levels for estradiol were 80.3, 70.4, and 79.9 pmol/L. In stratified analyses, however, prescription NSAID use was associated with lower testosterone, estradiol, and estrone levels in obese men and lower testosterone and dehydroepiandrosterone sulfate levels in inactive men. Conclusions While overall these data do not provide strong support for an association between NSAID use and hormone levels in men, prescription NSAIDs may decrease levels of certain estrogens and androgens in obese and inactive men.

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The Effect of Alcohol, Tobacco, and Aspirin Consumption on Seminal Quality among Healthy Young Men

Cited by 45 publications

References 25 publications

Association between tobacco exposure and reproductive parameters in adolescent males

Association between tobacco exposure and reproductive parameters in adolescent males

Does alcohol have any effect on male reproductive function? A review of literature

Non steroidal anti‐inflammatory drug use and levels of oestrogens and androgens in men

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