The effect of alcohol on neuroglia in the developing brain and in adults

Krawczyk-Marć, Izabela; Galiniak, Sabina; Sęk-Mastej, Anna; Marć, Mateusz; Orkisz, S; Wawrzyniak, Agata

doi:10.15584/ejcem.2018.4.11

Cited by 1 publication

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“…On chronic exposure, the most significant decreases were seen for adenosine and galactosylceramides, which play an important role in the CNS as they are the most abundant glycolipid components of myelin (Figure ). This observation is consistent with other studies which showed that long-term ethanol intake leads to myelin damage to various degrees . Ethanol-induced brain alterations were also highlighted by the lower relative concentrations of thiamine detected using the targeted approach, seen even after short-term administration.…”

Section: Discussionsupporting

confidence: 92%

“…This observation is consistent with other studies which showed that long-term ethanol intake leads to myelin damage to various degrees. 51 Ethanol-induced brain alterations were also highlighted by the lower relative concentrations of thiamine detected using the targeted approach, seen even after short-term administration. Because of its role as a co-enzyme (as thiamine pyrophosphate), thiamine has important functions in a range of biochemical pathways including the Krebs cycle, lipid metabolism, and the biosynthesis of neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic Phenotyping Study of Mouse Brains Following Acute or Chronic Exposures to Ethanol

et al. 2020

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The chronic and acute effect of ethanol administration on the metabolic phenotype of mouse brain was studied in a C57BL/6 mouse model of ethanol abuse using both untargeted and targeted ultra performance liquid chromatography-tandem mass spectrometry. Two experiments based on either chronic (8 week) exposure to ethanol of both male and female mice or acute exposure of male mice for 11 days, plus 2 oral gavage doses of 25% ethanol, were undertaken. Marked differences were found in amino acids, nucleotides, nucleosides, and related metabolites as well as a number of different lipids. Using untargeted metabolite profiling, acute ethanol exposure found significant decreases in several metabolites including nucleosides, fatty acids, glycerophosphocholine, and a number of phospholipids, while chronic exposure resulted in increases in several amino acids with notable decreases in adenosine, acetylcarnitine, and galactosylceramides. Similarly, targeted metabolite analysis, focusing on the hydrophilic fraction of the brain tissue extract, identified significant decreases in the metabolism of amino acids and derivatives, as well as purine degradation especially after chronic exposure to ethanol.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%