The effect of agmatine on the vascular reactivity in streptozotocin-diabetic rats

Özyazgan, Sibel; Bıçakçı, Burhan; Özaydın, Ahmet; Denizbaşı, Arzu; Ünlüer, Erol Erden; Akkan, Ahmet Gökhan

doi:10.1016/s1043-6618(03)00101-4

Cited by 15 publications

(17 citation statements)

References 36 publications

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“…The results of this work revealed that the endothelium-dependent relaxant response was reduced in aortas from STZ-induced diabetic rats, and this reduction in relaxant responses could be recovered partially by SAA treatment. Although some researchers asserted that the sensitivity to acetylcholine decreased in diabetes (Abebe 2008;Ozyazgan et al 2003), the results of this research, in accordance with those of many previous ones (Ozcelikay et al 1999;Silan 2008), revealed that diabetes decreased the responses to ACh in maximum relaxation but not the sensitivity (pD 2 ). SAA treatment reversed the decreased relaxant responses.…”

Section: Discussionsupporting

confidence: 91%

Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats

et al. 2009

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Section: Discussionsupporting

confidence: 91%

Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats

et al. 2009

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“…23) The results of this study revealed that the endothelium-dependent relaxant response was reduced in aortas from STZ-induced diabetic rats. Although some researchers asserted that the sensitivity to ACh decreased in diabetes, 24,25) the results of this research, in accordance with those of many previous ones, 21,25,26) revealed that diabetes decreased the responses to ACh in maximum relaxation but not the sensitivity.…”

Section: Discussionsupporting

confidence: 91%

Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta

et al. 2011

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The aim of this study was to ascertain the eŠects of a-lipoic acid (ALA) treatment on relaxant responses of acetylcholine (ACh) and isoprenaline (ISO) in aortic rings precontracted with serotonin (5-HT, 10 -6 M) obtained from streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in the rats by 50 mg/kg streptozotocin (STZ) via an intraperitoneal injection. Rat body and aorta weights were measured. The isometric tension to ACh (10 -9  3×10 -6 M) and ISO (10 -9  10 -4 M) of 5-HT-precontracted diabetic and non-diabetic rat (control), diabetic-ALA-treated, and ALA-treated aortas, in organ baths were recorded. Six weeks after STZ treatment blood glucose was elevated compared to control rats. In aortic rings from diabetic rats ACh and ISO-induced relaxations were impaired whereas endotheliumindependent relaxation to sodium nitroprusside (SNP) was unaŠected. ALA (100 mg/kg/day) treatment for 5 weeks enhanced ACh and ISO-induced relaxation in diabetic aortas. This recovering eŠect was via NO because prevented by incubating the vessels with N G -nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor). It may be assumed that ALA treatment in vivo, can protect against impaired vascular responsiveness in STZ-induced diabetic rats.

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“…AGM treatment improved endothelial-dependent relaxation impaired by HFD. AGM has been shown to stimulate eNOS enzyme to release NO (Ozyazgan et al 2003;El-Awady and Suddek 2014); in addition to possessing antioxidant and anti-inflammatory effects (El-Agamy et al 2014), these actions could explain its endothelial protective effects.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of insulin resistance in rats by agmatine: role of SREBP-1c, mTOR and GLUT-2

Sharawy

El‐Awady

Megahed

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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Insulin resistance is a serious health condition worldwide; however, its exact mechanisms are still unclear. This study investigates agmatine (AGM; an endogenous metabolite of L-arginine) effects on insulin resistance induced by high fructose diet (HFD) in rats and the possible involved mechanisms. Sprague Dawley rats were fed 60% HFD for 12 weeks, and AGM (10 mg/kg/day, orally) was given from week 9 to 12. AGM significantly reduced HFD-induced elevation in fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR) index and liver glycogen content from 3.44-, 3.62- and 2.07- to 2.59-, 2.78- and 1.3-fold, respectively, compared to the control group, while it increased HFD-induced reduction in glucose tolerance. Additionally, AGM significantly decreased HFD-induced elevation in serum triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels from 3.18-, 2.97- and 4.75- to 1.25-, 1.25- and 1.07-fold, respectively, compared to control group. Conversely, AGM had no significant effect on HFD-induced changes in fasting glucose, glycosylated hemoglobin, insulin tolerance and high density lipoprotein cholesterol. Furthermore, AGM significantly reduced HFD-induced elevation in mRNA expression of glucose transporter type-2 (GLUT-2), mammalian target of rapamycin (mTOR) and sterol regulatory element-binding protein-1c (SREBP-1c) without affecting that of peroxisome proliferator-activated receptor-alpha (PPAR-α) in the liver. Additionally, AGM enhanced ACh-induced aortic relaxation and attenuated liver steatosis induced by HFD. In conclusion, AGM may have a therapeutic potential in insulin resistance through suppressing SREBP-1c, mTOR and GLUT-2 in liver.

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The effect of agmatine on the vascular reactivity in streptozotocin-diabetic rats

Cited by 15 publications

References 36 publications

Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats

Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats

Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta

Attenuation of insulin resistance in rats by agmatine: role of SREBP-1c, mTOR and GLUT-2

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