The effect of aging on skin blood flow in the Wistar-Kyoto rat

Rendell, Marc; Milliken, Brian K.; McIntyre, Steven F.; Satterlee, Michele; Eckermann, August J.

doi:10.1016/0300-9629(95)00007-t

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Histological observations indicate that a difference exists in vascular bed composition between hairless plantar paw skin (rich in arterioles, venules, and arteriovenous anastomoses) and dorsal hairy skin (rich in capillaries) (27,28). Moreover, skin tissue blood flow is reportedly larger in the hairless skin than in hairy skin, and blood flow increases in response to warm temperature stimulus are also larger in the hairless skin (26,28). Differences in blood flow responses to CO 2 -water immer-sion at 35°C between the results of Ito et al and the present experiment might be due to differences in the composition of the tested vascular beds.…”

Section: Discussionmentioning

confidence: 98%

Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats

Hashimoto¹,

Yamamoto²

2004

Journal of Applied Physiology

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To investigate the effects of carbon dioxide (CO2) hot spring baths on physiological functions, head-out immersion of urethane-anesthetized, fursheared male Wistar rats was performed. Animals were immersed in water (30 or 35 degrees C) with high-CO2 content ( approximately 1,000 parts/million; CO2-water). CO2-water for bathing was made by using an artificial spa maker with normal tap water and high-pressure CO2 from a gas cylinder. When a human foot was immersed for 10 min in the CO2-water at 35 degrees C, the immersed skin reddened, whereas skin color did not change in normal tap water at the same temperature. Arterial blood pressure, heart rate (HR), underwater skin tissue blood flow, and temperatures of the colon and immersed skin were continuously measured while animals were immersed in a bathtub of water for approximately 30 min at room temperature (26 degrees C). Immersed skin vascular resistance, computed from blood pressure and tissue blood flow, was significantly lower in the CO2-water bath than in tap water at 30 degrees C, but no differences were apparent at 35 degrees C. HR of rats in CO2-water was significantly slower than in tap water at 35 degrees C. Decreased HR in CO2-water was inhibited by infusion of atenolol (beta1-adrenoceptor blocker), but it was unaffected by atropine (muscarinic cholinoceptor blocker). Theses results suggest that bradycardia in CO2 hot spring bathing is caused by inhibition of the cardiac sympathetic innervation. This CO2-water maker should prove a useful device for acquiring physiological evidence of balneotherapy.

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Section: Discussionmentioning

confidence: 98%

Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats

Hashimoto¹,

Yamamoto²

2004

Journal of Applied Physiology

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“…Tsuchida's (1979) 133 Xe blood flow measured demonstrated a clear decline in the deltoid region with advancing age. Rendell et al (1995) using LD observed a decline in blood flow with age both in humans and in experimental animals. With increasing age, capillary density has been reported to decline and the subepidermal capillary loops are said to be situated deeper within the dermis (Richard et al 1994).…”

Section: Sources Of Normal Variationmentioning

confidence: 99%

Normal variation in cutaneous blood content and red blood cell velocity in humans

et al. 1997

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This study was designed to determine normal variations in cutaneous blood content, red blood cell content and skin thickness in healthy human volunteers. The blood content (BC) of human skin and the velocity of red blood cells (RBV) has been comprehensively mapped over 30 anatomical sites in 28 volunteers between the age of 7 and 77 years using reflectance spectrophotometry (RFS) and laser Doppler (LD) techniques respectively. Total skin thickness, which may have a relationship with blood content, has been mapped at the same anatomical sites in six of the volunteers using two-dimensional array, 12 MHz ultrasound equipment. The major determinant of BC and RBV was found to be anatomical site. Regardless of age, gender or prior sun exposure, anatomical sites above the waist produced higher readings than below. BC and RBV were found to be dependent on age and gender at most sites with higher readings being observed in males and younger volunteers. The largest difference was seen in males under 55 years whose RFS readings above the waist were significantly higher than in older males or females of any age. Heavy prior sun exposure and skin thickness could not be demonstrated to impact on either RFS or LD readings independently of the effects of anatomical site, gender or age. In general, RFS and LD readings paralleled one another and correlated linearly at most anatomical sites. While RFS readings tended to decrease in the cranio-caudal direction, LD readings were relatively uniform across the body except for the head and groin where they were higher, and the abdomen where they were lower. The site-to-site variations in RFS readings observed in this study correspond well to capillary density variations noted in previous studies.

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The effect of polycythemia on skin blood flow in hypertensive rats

Rendell

McIntyre

Terando

et al. 1995

Comparative Biochemistry and Physiology Part A: Physiology

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The effect of aging on skin blood flow in the Wistar-Kyoto rat

Cited by 4 publications

References 26 publications

Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats

Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats

Normal variation in cutaneous blood content and red blood cell velocity in humans

The effect of polycythemia on skin blood flow in hypertensive rats

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The effect of aging on skin blood flow in the Wistar-Kyoto rat

Cited by 4 publications

References 26 publications

Decrease in heart rates by artificial CO2 hot spring bathing is inhibited by β1-adrenoceptor blockade in anesthetized rats

Decrease in heart rates by artificial CO2 hot spring bathing is inhibited by β1-adrenoceptor blockade in anesthetized rats

Normal variation in cutaneous blood content and red blood cell velocity in humans

The effect of polycythemia on skin blood flow in hypertensive rats

Contact Info

Product

Resources

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Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats

Decrease in heart rates by artificial CO₂ hot spring bathing is inhibited by β₁-adrenoceptor blockade in anesthetized rats