The effect of aging on fracture healing in the rat

Bak, Bue; Andreassen, Troels T.

doi:10.1007/bf02556022

Cited by 90 publications

(42 citation statements)

References 17 publications

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“…Conventional orthopaedic wisdom is that ''fractures in children heal faster than those in adults,'' and basic science studies in animals and clinical studies in humans appear to support this clinical experience 21,22 . However, basic science studies of partial transection of the anterior cruciate ligament and patellar tendon healing have suggested that the scar formed in skeletally mature animals is actually stronger than that formed in skeletally immature animals 8,23 .…”

Section: Histologic Resultsmentioning

confidence: 99%

The Effect of Skeletal Maturity on Functional Healing of the Anterior Cruciate Ligament

Murray¹,

Magarian²,

Harrison³

et al. 2010

Journal of Bone and Joint Surgery

140

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Section: Histologic Resultsmentioning

confidence: 99%

The Effect of Skeletal Maturity on Functional Healing of the Anterior Cruciate Ligament

Murray¹,

Magarian²,

Harrison³

et al. 2010

Journal of Bone and Joint Surgery

140

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“…Specifically, patient age was the most important factor in determining new bone density in a recent clinical study [XI. Experimentally, age-related skeletal deficits in intact rats as well as in those healing fractures have also been reported [4,11].…”

Section: Introductionmentioning

confidence: 99%

The effect of aging on distraction osteogenesis in the rat

Aronson

Gao

Shen

et al. 2001

Journal Orthopaedic Research

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The effect of age on bone formation in the limb lengthening model of distraction osteogenesis (DO) was investigated in two studies using Sprague-Dawley (SD) rats from two colonies at various ages (CAMM: 9 vs 24 months, Harlan: 4 vs 24 months). External fixators were placed on the right tibiae of 30 male SD rats (20 CAMM, 10 Harlan) and mid-diaphyseal osteotomies were performed. Distraction was performed at 0.2 mm bid for 20 days (CAMM) o r 14 days (Harlan). The experimental (DO) and control (contra-lateral) tibiae were removed for high-resolution radiography and decalcified histology. Videomicroscopy was used to quantitate radiodensity, histology (matrix type) and relative areas of cell proliferation. which was identified by proliferating cell nuclear antigen (PCNA) immunochemistry. Both studies demonstrated an age-related decrease in the percent mineralized bone (radiodensity) in the distraction gap (CAMM 9 vs 24 months: 68% vs 51%, P < 0.003; Harlan 4 vs 24 months: 95% vs 36%. P < 0.001) and no significant colony or distraction time-specific difference was seen between the two colonies of 24-month-old rats.Histology was performed on the Harlan rats. The DO gaps in the 24-month-old rats demonstrated less endosteal new bone compared to the 4-month-old rats ( P < 0.01), but equivalent periosteal new bone. Tn 4-month-old rats, PCNA-immunostained cells were organized along the primary matrix front (where the first deposition of osteoid occurs) extending across both periosteal and endosteal surfaces. In 24-month-old rats, PCNA + cells were organized in zones along the periosteal new bone fronts only and irregularly scattered throughout the endosteal gap within a fibrovascular non-ossifying matrix. These results indicate that 24-monthold rats have a relative deficit in endosteal bone formation which may not be related to cell proliferation but rather to cell organization. This model reflects the clinical situation where radiographic findings in older patients demonstrate significant delays in mineralization during DO. We believe this model of DO in aged rats presents unique in vivo opportunities to test hypotheses concerning (1) the effects of aging on bone repair, (2) the effects of pharmacological agents on bone repair in a geriatric setting. and (3) to study the mechanisms underlying DO.

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“…Displacement is more common, and efficacies of some fracture repair techniques decrease relative to younger healthy patients. [3][4][5] Displaced distal radius fractures typically are repaired by closed reduction and casting or open reduction with internal plate fixation, although this treatment dichotomy can be inadequate for certain elderly patients. Re-displacement rates after closed reduction with splinting 6 approach 50%.…”

mentioning

confidence: 99%