The effect of aging and arteriosclerosis on human skin blood flow

Tsuchida, Yukihide

doi:10.1016/0923-1811(93)90764-g

Cited by 56 publications

(23 citation statements)

References 9 publications

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“…If EPC-1 contributes similarly to barrier function at this interface but declines with increasing age, this suggests that there would be an increase in vascular dysplasias and an increase in diseases that result from abnormal blood vessel growth. In fact, it is well documented that vascular dysplasias, such as senile angiomata, cherry angiomatas, de Morgan spots, angiokeratomas, purpura, palor, venous lake formation, and telangiectasias, are observed in virtually all individuals over the age of 70 (Ryan, 1969;Montagna and Carlisle, 1979;Balin and Lin, 1989;Tsuchida, 1993). Despite these numerous cutaneous disorders in the elderly, however, it is generally accepted that angiogenesis is delayed or impaired during aging (Yamaura and Matsuzawa, 1980;Pili et al, 1994;Sadoun and Reed, 2003).…”

Section: Discussionmentioning

confidence: 96%

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

Francis

Appel

Meyer

et al. 2004

Journal of Investigative Dermatology

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EPC-1/PEDF (early population doubling level cDNA-1/retinal pigmented epithelium-derived factor) is a single-copy, quiescence-specific gene that is transcribed into a 1.5 kb mRNA and then translated into a 50 kDa secreted protein that is a potent inhibitor of angiogenesis. EPC-1 expression has been detected in a number of cultured cell lines, including lung and skin fibroblasts, retinal pigmented epithelial cells, and endometrial stromal fibroblasts. Furthermore, its expression has been shown to decline during replicative aging of these cells in culture. In this report, we describe our examination of the age-related changes in EPC-1 expression in situ in skin sections from donors of different ages. EPC-1 mRNA is detected primarily in the dermal layer of the skin and its expression declines with increasing donor age. This decline is statistically significant between young (less than 31 years old) and middle-aged (between 30 and 60 years old) donors, with the decline becoming less dramatic at older ages. This age-related decline in the expression of an angiogenic inhibitor contributes to the imbalance of angiogenic modulators that is observed during aging. In fact, this decline may reflect a compensatory change to help reverse the decline of angiogenesis marked by reduced abundance of microvessels. This downregulation of an angiogenesis inhibitor may, in turn, play a critical role in the development of diseases caused by abnormal vascularization. The potential role of the age-associated decline in EPC-1 expression in tissue remodeling and in the development of skin diseases with excessive angiogenesis may provide new insights into disease prevention.

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Section: Discussionmentioning

confidence: 96%

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

Francis

Appel

Meyer

et al. 2004

Journal of Investigative Dermatology

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“…It has long been appreciated that blood flow to the skin, the largest organ in the body, is reduced by 40% between the ages of 20 to 70 years (Tsuchida, 1993). This likely reflects changes in the microcirculation.…”

Section: Age-related Anatomical and Functional Changes In The Micmentioning

confidence: 99%

The effect of aging on the cutaneous microvasculature

Bentov

Reed

2015

Microvascular Research

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Aging is associated with a progressive loss of function in all organs. Under normal conditions the physiologic compensation for age-related deficits is sufficient, but during times of stress the limitations of this reserve become evident. Explanations for this reduction in reserve include the changes in the microcirculation that occur during the normal aging process. The microcirculation is defined as the blood flow through arterioles, capillaries and venules, which are the smallest vessels in the vasculature and are embedded within organs and tissues. Optimal strategies to maintain the microvasculature following surgery and other stressors must use multifactorial approaches. Using skin as the model organ, we will review the anatomical and functional changes in the microcirculation with aging, and some of the available clinical strategies to potentially mitigate the effect of these changes on important clinical outcomes.

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“…This helps explain the frequent bruising seen in the elderly. Tshudi also discovered that skin blood flow is decreased by 40 % by the age of 70 from that of a 20 year old [15]. There is also a decrease size of lymphatic vessels thereby decreasing lymphatic drainage leading to increased edema in the elderly [16].…”

Section: Introductionmentioning

confidence: 96%

Skin Manifestations of Internal Disease in Older Adults

Markus¹,

Perry²,

Lear³

2015

Curr Geri Rep

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The skin is the largest and most visible organ in the body and can give diagnostic clues of systemic illness. These clues often become obscured through the normal aging process. The purpose of this review is to give an overview of the normal skin changes seen with aging and then discuss new findings with regards to cutaneous signs of systemic disease in the elderly. We performed a literature search on cutaneous manifestations of internal disease and limited our search to articles published within the last 5 years. We then narrowed down the articles on conditions that primarily affect the adults over the age of 65; conditions commonly seen in the elderly as well as new findings which we felt were of great significance. Ultimately, we hope to update the reader on new cutaneous diagnostic tools of internal disease.

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The effect of aging and arteriosclerosis on human skin blood flow

Cited by 56 publications

References 9 publications

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

The effect of aging on the cutaneous microvasculature

Skin Manifestations of Internal Disease in Older Adults

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