The effect of ageing on confrontation naming in healthy older adults: a three-level meta-analysis

Wen, Hao; Dong, Yanping

doi:10.1080/20445911.2023.2184745

Cited by 5 publications

(5 citation statements)

References 152 publications

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“…Without time pressure older adults scored higher than young adults in picture naming tests in some studies 55,56 . Studies that revealed aging‐related declines in naming scores might have included some participants with preclinical AD 57–59 …”

Section: Discussionmentioning

confidence: 99%

“…55,56 Studies that revealed aging-related declines in naming scores might have included some participants with preclinical AD. [57][58][59] It remains to be determined how the present findings can be accommodated within theoretical frameworks that assume aging effects on naming reflect difficulties with accessing phonology, 60,61 or executive control impairments. 62 While it seems reasonable to assume that increased age leads to richer semantic representations, 63 it is not clear why aging would increase the ability to access phonology only after temporarily failing to do so (in fact the opposite is typically assumed, especially for proper name retrieval 5 ).…”

Section: How Does Ad Pathology Versus Healthy Aging Affect Picture Na...mentioning

confidence: 94%

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The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

Gollan

Garcia

Stasenko

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONEvidence on the onset of naming deficits in Alzheimer's disease (AD) is mixed. Some studies showed an early decline, but others did not. The present study introduces evidence from a novel naming test.METHODSCognitively normal (n = 138), mild cognitive impairment (MCI; n = 21), and Alzheimer's disease (AD; n = 31) groups completed an expanded Multilingual Naming Test with a time‐pressured administration procedure (MINT Sprint 2.0). Cerebrospinal fluid biomarkers classified participants as true controls (n = 61) or preclinical AD (n = 26).RESULTSTotal correct MINT Sprint 2.0 scores exhibited good sensitivity and specificity (>0.85) for discriminating true controls from cognitively impaired (MCI/AD) groups and showed significant differences between true controls and preclinical AD groups. Time measurement did not improve classification, but percent resolved scores exhibited promise as an independent AD marker.DISCUSSIONNaming deficits can be detected in the earliest stages of AD with tests and procedures designed for this purpose.

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Section: Discussionmentioning

confidence: 99%

Section: How Does Ad Pathology Versus Healthy Aging Affect Picture Na...mentioning

confidence: 94%

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

Gollan

Garcia

Stasenko

et al. 2023

Alzheimer's & Dementia

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show abstract

“…Longitudinal studies would therefore be more appropriate to capture all the regions potentially underlying each mechanism. Future research should also investigate age-invariant mechanisms associated with high cognitive reserve for a more graceful language processing decline as age advances (Brosnan et al, 2023;Oosterhuis et al, 2023;Wen & Dong, 2023;Wulff et al, 2022). Further studies should specify the factors associated with the recruitment of subcortical structures, like the bilateral thalamus and left putamen, in late adulthood.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Modeling the neurocognitive dynamics of language across the lifespan

Guichet,

Banjac,

Achard

et al. 2024

Human Brain Mapping

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Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and language production (LP). Examining resting‐state fMRI and neuropsychological data from 628 healthy adults (age 18–88) from the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover the neural mechanisms underlying this variability. At the cognitive level, our findings suggest that LP is not an isolated function but is modulated throughout the lifespan by the extent of inter‐cognitive synergy between semantic and domain‐general processes. At the cerebral level, we show that default mode network (DMN) suppression coupled with fronto‐parietal network (FPN) integration is the way for the brain to compensate for the effects of dedifferentiation at a minimal cost, efficiently mitigating the age‐related decline in LP. Relatedly, reduced DMN suppression in midlife could compromise the ability to manage the cost of FPN integration. This may prompt older adults to adopt a more cost‐efficient compensatory strategy that maintains global homeostasis at the expense of LP performances. Taken together, we propose that midlife represents a critical neurocognitive juncture that signifies the onset of LP decline, as older adults gradually lose control over semantic representations. We summarize our findings in a novel synergistic, economical, nonlinear, emergent, cognitive aging model, integrating connectomic and cognitive dimensions within a complex system perspective.

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“…The decline in LP varies among older individuals, exhibiting significant variability (Gordon et al, 2018; Wen & Dong, 2023) linked to cognitive reserve differences (Oosterhuis et al, 2023; Perneczky, 2019). As highlighted by previous studies (Baciu et al, 2021; Wulff et al, 2022) this variability depends on various cognitive reserve factors such as education, social, intellectual, physical, and leisure activities (Brosnan et al, 2023; Perneczky, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of White Matter Architecture in Lexical Production among Middle-Aged Adults

Guichet,

Roger,

Attyé

et al. 2024

Preprint

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This study aimed to elucidate the white matter changes associated with lexical production (LP) difficulties that typically emerge in middle age, resulting in increased naming latencies. To delay the onset of LP decline, middle-aged adults may rely on domain-general (DG) and language-specific (LS) compensatory mechanisms as proposed by the LARA model (Lexical Access and Retrieval in Aging). However, our knowledge of the white matter changes supporting these mechanisms remains incomplete. Based on a sample of 155 middle-aged adults from the CAMCAN cohort, we combined dimensionality reduction techniques with multivariate statistical methods to jointly examine the relationships between diffusion-weighted imaging and LP-related neuropsychological data. Our findings (i) show that midlife constitutes a pivotal period marked by a discontinuity in brain structure within distributed networks within dorsal, ventral, and anterior cortico-subcortical pathways, and (ii) reveal that this discontinuity signals a neurocognitive transition around age 53-54, marking the onset of LP decline. Indeed, our results propose that middle-aged adults may initially adopt a “semantic strategy” to compensate for initial LP challenges. Still, this strategy may be compromised when late middle-aged adults (age 55-60) lose the ability to exert cognitive control over semantic representations (i.e., reduced semantic control).In summary, our study advances our comprehension of brain structure changes that underpin the neurocognitive profile of LP in middle age. Specifically, we underscore the importance of considering the interplay between DG and LS processes when studying the trajectory of LP performance in healthy aging. Furthermore, these findings offer valuable insights into identifying predictive biomarkers related to the compensatory dynamics observed in midlife, which can help understand language-related neurodegenerative pathologies.HighlightsMidlife constitutes a pivotal period characterized by a discontinuity in brain structure.Early middle-aged adults (age 45-55) adopt a “semantic strategy” to facilitate semantic access and sustain lexical production (LP) performances.Late middle-aged adults (age 55-60) gradually lose the ability to exert cognitive control over semantic representations, marking the onset of LP decline.

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The effect of ageing on confrontation naming in healthy older adults: a three-level meta-analysis

Cited by 5 publications

References 152 publications

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

Modeling the neurocognitive dynamics of language across the lifespan

Dynamics of White Matter Architecture in Lexical Production among Middle-Aged Adults

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