The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength

Farrow, Matthew; Biglands, John; Tanner, Steven F.; Clegg, Andrew; Brown, Lesley; Hensor, Elizabeth M A; O’Connor, Philip; Emery, Paul; Tan, Ai Lyn

doi:10.1007/s40520-020-01530-2

Cited by 40 publications

(44 citation statements)

References 39 publications

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“…It is widely known that the natural process of ageing involves deleterious effects on the skeletal muscle system and that these effects are more evident in older adults [40,41]. An important finding of this study was that a period of two years is enough to observe deleterious effects of ageing on the muscle strength, muscle mass, and cognition level of sedentary older women (Table 3).…”

Section: Discussionmentioning

confidence: 64%

Effects of Resistance Training Program on Muscle Mass and Muscle Strength and the Relationship with Cognition in Older Women

et al. 2021

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The aim of this study was to study the effects of a resistance training programme on Maximal Dynamic Strength (MDS) and muscle morphology of the upper limbs (UL) and lower limbs (LL), as well as to analyse their association with cognition, in a population of older women. The study had a duration of 24 months and a total of 93 Chilean older women participated. The participants were divided into two groups: the Physical Activity Group (PAG, n = 45, age (X ± SD) 77.93 ± 3.54 years), and the Sedentary Group (SG, n = 48, age (X ± SD) 77.71 ± 3.41 years). The PAG carried out a muscle strength training routine twice per week. The following variables were evaluated: muscle function through maximal dynamic strength (1RM), muscle morphology through arm and calf circumference (AC and CC, respectively), and cognition (Mini Mental State Examination: MMSE). The results show that the SG recorded significant decreases (percent changes; p < 0.05) in the analysed variables: MMSE (−3.5%), MDS in UL (−3.3%), MDS in LL (−4.1%), AC (−4.5%), CC (−4.1%), and BMI (−3.1%). However, the PAG improved significantly in all the analysed variables except in BMI: MMSE (3.9%), MDS in UL (3.6%), MDS in LL (3.5%), AC (1.8%), and CC (2.5%). Moreover, there was a significant association (p < 0.05) between the changes in the muscle strength variables and the changes in cognition level. Therefore, it can be concluded that a two-year muscle strength training programme (load intensity between 30–55% 1RM) in older women improves Maximal Dynamic Strength in UL and LL, as well as muscle mass in arms and calves. Furthermore, it can be asserted that the changes in muscle strength levels could predict the changes in the levels of cognition in older women.

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Section: Discussionmentioning

confidence: 64%

Effects of Resistance Training Program on Muscle Mass and Muscle Strength and the Relationship with Cognition in Older Women

et al. 2021

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“…The imaging protocol has been described previously. 26 Images of the dominant thigh (the right if the participant was unsure) were acquired using two small four-channel flex coils.…”

Section: Mri Measurementsmentioning

confidence: 99%

“…Muscle volume estimates were obtained using a semiautomated algorithm. 26 The algorithm segmented muscle from the FF maps generated by the VIBE Dixon analysis using a FF threshold of <50%.…”

Section: Mri Measurementsmentioning

confidence: 99%

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Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

et al. 2021

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imaging (MRI)-based measurements of T2, fat fraction, diffusion tensor imaging, and muscle volume can detect differences between the muscles of myositis patients and healthy controls, and to identify how they compare with semi-quantitative MRI diagnosis. MATERIALS AND METHODS: Sixteen myositis patients and 16 age-and gender-matched healthy controls underwent MRI of their thigh. Quantitative MRI measurements and radiologists' semi-quantitative scores were assessed. Strength was assessed using an isokinetic dynamometer. RESULTS: Fat fraction and T2 values were higher in myositis patients whereas muscle volume was lower compared to healthy controls. There was no difference in diffusion. Muscle strength was lower in myositis patients compared to healthy controls. In a subgroup of eight patients, scored as unaffected by radiologists, T2 values were still significantly higher in myositis patients. CONCLUSIONS: Quantitative MRI measurements can detect differences between myositis patients and healthy controls. Changes in the muscles of myositis patients, undetected by visual, semi-quantitative scoring, can be detected using quantitative T2 measurements. This suggests that MRI T2 values may be useful for the management of myositis patients.

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“…Nevertheless, qMRI can differentiate the muscle properties between the ages and has been shown to correlate with muscle outcome measures. Therefore, it shows potential promise as a tool to help understand the varying factors that can affect muscle in rheumatic diseases ( 104 ).…”

Section: Muscle Imaging In Inflammatory Rheumatic Diseasesmentioning

confidence: 99%

Novel Muscle Imaging in Inflammatory Rheumatic Diseases—A Focus on Ultrasound Shear Wave Elastography and Quantitative MRI

et al. 2020

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In recent years, imaging has played an increasing role in the clinical management of patients with rheumatic diseases with respect to aiding diagnosis, guiding therapy and monitoring disease progression. These roles have been underpinned by research which has enhanced our understanding of disease pathogenesis and pathophysiology of rheumatology conditions, in addition to their key role in outcome measurement in clinical trials. However, compared to joints, imaging research of muscles is less established, despite the fact that muscle symptoms are very common and debilitating in many rheumatic diseases. Recently, it has been shown that even though patients with rheumatoid arthritis may achieve clinical remission, defined by asymptomatic joints, many remain affected by lingering constitutional systemic symptoms like fatigue, tiredness, weakness and myalgia, which may be attributed to changes in the muscles. Recent improvements in imaging technology, coupled with an increasing clinical interest, has started to ignite new interest in the area. This perspective discusses the rationale for using imaging, particularly ultrasound and MRI, for investigating muscle pathology involved in common inflammatory rheumatic diseases. The muscles associated with rheumatic diseases can be affected in many ways, including myositis—an inflammatory muscle condition, and myopathy secondary to medications, such as glucocorticoids. In addition to non-invasive visual assessment of muscles in these conditions, novel imaging techniques like shear wave elastography and quantitative MRI can provide further useful information regarding the physiological and biomechanical status of the muscle.

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The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength

Cited by 40 publications

References 39 publications

Effects of Resistance Training Program on Muscle Mass and Muscle Strength and the Relationship with Cognition in Older Women

Effects of Resistance Training Program on Muscle Mass and Muscle Strength and the Relationship with Cognition in Older Women

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

Novel Muscle Imaging in Inflammatory Rheumatic Diseases—A Focus on Ultrasound Shear Wave Elastography and Quantitative MRI

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