The Effect of Age on the Hydroxylation of Amylobarbitone Sodium in Man

Irvine, Rob; Grove, Jeffrey; Toseland, P. A.; Trounce, J. R.

doi:10.1111/j.1365-2125.1974.tb00204.x

Cited by 65 publications

(17 citation statements)

References 4 publications

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“…(Figure 2). Larodopa reached equilibrium concentrations between 20 and (Shy & Drager, 1960 Stevenson, 1971;Irvine, Grove, Toseland & Trounce, 1974;Castleden, Kaye & Parsons, 1975), and hepatic function in the Parkinsonian age group (Thompson & Williams, 1965) are impaired.…”

Section: Resultsmentioning

confidence: 99%

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

Morris

Parsons

Trounce

et al. 1976

Brit J Clinical Pharma

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I The concurrent administration of levodopa with a decarboxylase inhibitor produced a plasma concentration/time curve comparable with 1/4 to 1/5 of the dose of levodopa given alone. 2 There was no evidence to suggest that the decarboxylase inhibitor slowed the rate of elimination of levodopa from plasma. 3 Metoclopramide (Maxolon) increased the rate of levodopa absorption. Higher plasma concentrations of levodopa during the first 2 h after dosing were followed by lower plasma concentrations during the third and fourth hours. The amount of levodopa absorbed after Larodopa as indicated by the AUC was not altered by adding metoclopramide. 4 None of the current preparations of levodopa produced sustained plasma concentrations. 5In vitro testing confirmed that Brocadopa Temtabs tablets disintegrate and dissolve slowly. In vivo, Brocadopa Temtabs behaved as a slow release preparation but it did not produce sustained plasma concentrations of levodopa.

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Section: Resultsmentioning

confidence: 99%

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

Morris

Parsons

Trounce

et al. 1976

Brit J Clinical Pharma

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“…Likewise Streicher & Garbus (1955) showed that hexobarbitone sleeping time was prolonged in aged male rats, though this was not seen in the females Irvine et al (1974),. studying elderly humans, showed some evidence of reduced hydroxylation of amylobarbitone, and Jori, Di Salle & Quadri (1972) found similar results with aminopyrine O'Malley et al (1971).…”

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confidence: 91%

Phenazone (antipyrine) metabolism and distribution in young and elderly adults

Liddell

Williams

Briant

1975

Clin Exp Pharma Physio

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S U M M A R Y 1. The plasma half-life and apparent volume of distribution of phenazone (antipyrine) was studied in twenty-six normal adults (20-40 years of age) and twenty-six geriatric patients. 2.A wide range of values for plasma half-life was recorded in both groups (young 7.7-19.9 h, elderly 9.5-30.1 h) but the mean plasma half-life for the geriatric group (16.8 h; s.e.m. = 5.9) was significantly longer (P

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“…Such an increase could result from decreased efficiency of drug metabolizing enzymes. Reduced levels of cytochrome P-450 with advancing age has been directly demonstrated in rats (Kato & Takanaka, 1968a), and this decrease in in vitro enzyme activity is paralleled by impairment of drug metabolizing activity (Kato & Takanaka, 1968b (O'Malley, Crooks, Duke & Stevenson, 1971), and the rate of hydroxylation of amylobarbitone is reduced in the elderly (Irvine, Grove, Toseland & Trounce, 1974). Drugs may also accumulate as a result of impairment of renal function associated with advancing age (Shock, 1946).…”

Section: Introductionmentioning

confidence: 99%

The effect of age on plasma levels of propranolol and practolol in man.

Castleden¹,

Kaye²,

Parsons³

1975

Brit J Clinical Pharma

137

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1Plasma levels of propranolol and practolol were measured in groups of elderly and young subjects, after the oral administration of propranolol (40 mg) and practolol (200 mg) on separate occasions. 2 At all sampling times the mean plasma propranolol level in the group of elderly subjects was substantially greater than the corresponding level in the group of young subjects, there being a significant difference between the two, and a fourfold difference in the mean peak levels. 3 After practolol, there was no significant difference between the mean plasma concentrations of the drug in the two groups for the first 2 hours. Subsequently, the mean plasma levels in the group of elderly subjects were somewhat higher than the corresponding levels in the young group, the differences between the two reaching significance. 4 It is suggested that there is a need to substantially reduce the dose of propranolol given to elderly patients. With practolol, however, no reduction is necessary providing renal function is normal for the patient's age.

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The Effect of Age on the Hydroxylation of Amylobarbitone Sodium in Man

Cited by 65 publications

References 4 publications

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

Phenazone (antipyrine) metabolism and distribution in young and elderly adults

The effect of age on plasma levels of propranolol and practolol in man.

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